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A brominated secondary metabolite synthesized by the cyanobacterial symbiont of a marine sponge and accumulation of the crystalline metabolite in the sponge tissue
The dictyoceratid marine sponge Dysidea herbacea (Keller, 1889) is common in shallow waters of the tropical Pacific Ocean. Polybrominated biphenyl ethers such as… Expand
Cyanobacterial symbiont biosynthesis of chlorinated metabolites fromDysidea herbacea (Porifera)
The tropical marine spongeDysidea herbacea contains large numbers of a symbiotic filamentous cyanobacterium identified on the basis of a detailed ultrastructural study asOscillatoria spongeliae. We… Expand
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
- G. Newton, M. D. Unson, +5 authors R. C. Fahey
- Biology, Medicine
- Biochemical and biophysical research…
- 16 February 1999
Mycothiol (MSH) is the major low molecular weight thiol in mycobacteria. Two chemical mutants with low MSH and one with no MSH (strain 49) were produced in Mycobacterium smegmatis mc2155 to assess… Expand
An immunoassay for the detection and quantitative determination of mycothiol.
- M. D. Unson, G. Newton, C. Davis, R. C. Fahey
- Chemistry, Medicine
- Journal of immunological methods
- 1 May 1998
Mycothiol (MSH) is a glycosylated derivative of N-acetylcysteine that may have antioxidant functions in mycobacteria and other actinomycetes. To develop a highly specific assay for MSH, we… Expand
The chemistry of some sponges and their symbionts
From both ecological and biomedical viewpoints, it has become important to know whether the metabolites isolated from sponges are produced by symbiotic micro-organisms. Certain halogenated… Expand
New polychlorinated amino acid derivatives from the marine sponge Dysidea herbacea
A new series of polychlorinated amino acid derivatives were isolated from the tropical marine sponge Dysidea herbacea (Dictyoceratida). Two major hexachlorinated metabolites, dysideathiazole (4) and… Expand
Improved Methods for Immunoassay of Mycothiol
- M. D. Unson, G. Newton, K. Arnold, C. Davis, R. C. Fahey
- Biology, Medicine
- Journal of Clinical Microbiology
- 1 July 1999
ABSTRACT Improved enzyme-linked immunosorbent assay (ELISA) methods have been developed for the determination of femtomole amounts of mycothiol (MSH), the main low-molecular-weight thiol in… Expand
New Metabolites from Marine Sponges: Are Symbionts Important?
The Chemistry of Some Sponges and Their Symbionts.