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A brominated secondary metabolite synthesized by the cyanobacterial symbiont of a marine sponge and accumulation of the crystalline metabolite in the sponge tissue
Coupled gas chromatography—mass spectrometry and proton nuclear magnetic-resonance spectroscopy revealed that the major brominated Compound 1 isolated from the intact symbiotic association is found in the cyanobacteria and not in the sponge cells or heterotrophic bacteria, suggesting that the production of the compound is due to the Cyanobacterium.
Cyanobacterial symbiont biosynthesis of chlorinated metabolites fromDysidea herbacea (Porifera)
The flow-cytometric separation of the symbiont from the sponge cells is reported, and it is demonstrated by chemical analyses that a unique group of polychlorinated compounds isolated from the whole sponge tissue is limited to the cyanobacterial filaments, whereas the accompanying sesquiterpenoids are found only in the Sponge cells.
Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.
- G. Newton, M. D. Unson, R. C. Fahey
- Biology, ChemistryBiochemical and biophysical research…
- 16 February 1999
The results indicate that MSH and GlcN-Ins are not essential for in vitro survival of mycobacteria but may play significant roles in determining the sensitivity of myCobacteria to environmental toxins.
The chemistry of some sponges and their symbionts
Recent studies concerning the origin of bioactive metabolites from lithistid sponges, some of which contain filamentous micro-organisms, are presented.
New polychlorinated amino acid derivatives from the marine sponge Dysidea herbacea
A new series of polychlorinated amino acid derivatives were isolated from the tropical marine sponge Dysidea herbacea (Dictyoceratida). Two major hexachlorinated metabolites, dysideathiazole (4) and…
An immunoassay for the detection and quantitative determination of mycothiol.
Improved Methods for Immunoassay of Mycothiol
- M. D. Unson, G. Newton, K. Arnold, C. Davis, R. C. Fahey
- Biology, ChemistryJournal of Clinical Microbiology
- 1 July 1999
ABSTRACT Improved enzyme-linked immunosorbent assay (ELISA) methods have been developed for the determination of femtomole amounts of mycothiol (MSH), the main low-molecular-weight thiol in…
New Metabolites from Marine Sponges: Are Symbionts Important?
The Chemistry of Some Sponges and Their Symbionts.