• Publications
  • Influence
Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML
Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genesExpand
  • 187
  • 18
  • PDF
Natural products reveal cancer cell dependence on oxysterol-binding proteins.
Cephalostatin 1, OSW-1, ritterazine B and schweinfurthin A are natural products that potently, and in some cases selectively, inhibit the growth of cultured human cancer cell lines. The cellularExpand
  • 164
  • 11
Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116).Expand
  • 71
  • 9
  • PDF
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
Inspired by the usefulness of small molecules to study membrane traffic, we used high-throughput synthesis and phenotypic screening to discover secramine, a molecule that inhibits membrane trafficExpand
  • 145
  • 8
  • PDF
Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein
Summary Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (e.g., poliovirus,Expand
  • 133
  • 6
  • PDF
Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays
Understanding the cellular function of a protein usually requires a means to alter the function. This is commonly done by mutating the gene encoding the protein (genetic approach). It can also beExpand
  • 152
  • 4
Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAKExpand
  • 17
  • 3
Biomimetic synthesis of (-)-longithorone A.
An enantioseletive, biomimetic synthesis of (-)-longithorone A has been achieved using an intermolecular/transannular Diels-Alder sequence which provides some support for the proposed biosynthesis.Expand
  • 140
  • 1
  • PDF
Enantioselective total synthesis of hyperforin.
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-openingExpand
  • 59
  • 1
Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP.
Enteroviruses, e.g., polio-, coxsackie- and rhinoviruses, constitute a large genus within the Picornaviridae family of positive-strand RNA viruses and include many important pathogens linked to aExpand
  • 41
  • 1