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Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.
TLDR
Light-activated vertebrate RO4 and green algae ChR2 allow the antagonistic control of neuronal function within ms to s in a precise, reversible, and noninvasive manner in cultured neurons and intact vertebrate spinal cords.
G-protein mediated gating of inward-rectifier K+ channels.
TLDR
The main objective of this review is to assess the current understanding of the G-protein modulation of GIRK channels and their physiological importance in mammals.
RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal Neurons by Regulating Gi/o- Mediated Inhibition of Presynaptic Ca2+ Channels
TLDR
It is demonstrated that R GS2 increases synaptic vesicle release by downregulating the G(i/o)-mediated presynaptic Ca(2+) channel inhibition and therefore provides an explanation of how regulation of RGS2 expression can modulate the function of neuronal circuits underlying behavior.
Synaptic Localization and Presynaptic Function of Calcium Channel β4-Subunits in Cultured Hippocampal Neurons*
TLDR
Using retrovirus-mediated gene transfer in cultured hippocampal neurons, it is demonstrated that functional GFP-β4 constructs colocalize with the synaptic vesicle marker synaptobrevin II and endogenous P/Q-type channels, indicating that β4-subunits are localized to synaptic sites.
Patterning neuronal connections by chemorepulsion: the semaphorins
TLDR
This review will concentrate on a large and growing family of chemorepellents, the semaphorins, which contains both secreted and membrane-bound proteins expressed in many neuronal and non-neuronal tissues of invertebrates and vertebrates.
Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations
TLDR
The results show that the ataxia, dyskinesia, and absence epilepsy caused by inherited disorders of the P/Q-type channel arise from signaling defects beginning in late infancy, revealing an early window of opportunity for therapeutic intervention.
Spinocerebellar Ataxia Type 6 Protein Aggregates Cause Deficits in Motor Learning and Cerebellar Plasticity
TLDR
The results suggest that the polyQ carrying the CT fragment of the P/Q-type channel is sufficient to cause SCA6 pathogenesis in mice and identifies EBC as a new diagnostic strategy to evaluate Ca2+ channel-mediated human diseases.
Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels
TLDR
The current knowledge about G protein-coupled receptors and ion channels involved in the regulation of serotonergic system are reviewed, how their regulation is modulating the intrinsic activity ofserotonergic neurons and its transmitter release are discussed and the latest methods for controlling the modulation of serotonin release and intracellular signaling in serotonergy neurons in vitro and in vivo are discussed.
New roles for RGS2, 5 and 8 on the ratio‐dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes
TLDR
The ratio dependence of receptor‐mediated activation and deactivation and the influence of new members of the RGS protein family on GIRK currents are investigated by coexpressing the recombinant protein subunits in Xenopus oocytes and further analysis of the whole cell currents.
Competitive and Synergistic Interactions of G Protein β2 and Ca2+ Channel β1b Subunits with Cav2.1 Channels, Revealed by Mammalian Two-hybrid and Fluorescence Resonance Energy Transfer Measurements*
TLDR
The results suggest that the G protein alters the orientation and/or association between the Ca2+ channel β and α12.1 subunits, which involves the C terminus of the α1 subunit and may corresponds to a new conformational state of the channel.
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