• Publications
  • Influence
Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector
ABSTRACT Adeno-associated viruses (AAVs) are being developed as gene therapy vectors, and their efficacy could be improved by a detailed understanding of their viral capsid structures. AAV serotype 8Expand
  • 176
  • 8
  • PDF
A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung.
Advances in gene therapy vectors and techniques hold promise for treatment of many inherited and acquired diseases. For lung indications, especially those involving the epithelium, delivery of theExpand
  • 90
  • 4
The population genetics of the self-incompatibility polymorphism in Papaver rhoeas. VII. The number of S-alleles in the species
The results obtained from the cross-classification of the S-alleles of a sample of 30 plants raised from the seed taken from a Spanish population against those of a sample taken from a BritishExpand
  • 54
  • 1
The population genetics of the self-incompatibility polymorphism in Papaver rhoeas. V. Cross-classification of the S-alleles of samples from three natural populations
The results obtained from a comprehensive cross-classification of the self-incompatibility alleles from three natural populations of Papaver rhoeas (R102, R104 and R106) indicate that no less than 23Expand
  • 36
  • 1
Advances in the directed evolution of proteins.
Natural evolution has produced a great diversity of proteins that can be harnessed for numerous applications in biotechnology and pharmaceutical science. Commonly, specific applications requireExpand
  • 58
  • PDF
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.
Adeno-associated viruses (AAVs) are actively being developed for clinical gene-therapy applications and the efficiencies of the vectors could be significantly improved by a detailed understanding ofExpand
  • 24
  • PDF
The population genetics of the self-incompatibility polymorphism in Papaver rhoeas. VI. Estimation of the overlap between the allelelic complements of a pair of populations
The data obtained by cross-classifying the self-incompatibility (S–) alleles of samples taken at random from three natural populations of Papaver rhoeas, presented in the previous paper (Lawrence etExpand
  • 20
The population genetics of the self-incompatibility polymorphism in Papaver rhoeas. X. An association between incompatibility genotype and seed dormancy
Further analysis of data presented in a previous paper (Lane & Lawrence, 1995) has revealed an association between incompatibility genotype and seed dormancy such that the seed of crosses in whichExpand
  • 26
The population genetics of the self-incompatibility polymorphism in Papayer rhoeas. VIII. Sampling effects as a possible cause of unequal allele frequencies
This paper considers the hypothesis that the unequal S-allele frequencies in the British populations of Papaver rhoeas we have examined are caused by a sampling effect over and above that due toExpand
  • 12
Genetics of seed dormancy in Papaver rhoeas
Seed dormancy in a cross between wild Papaver rhoeas and its ‘Shirley’ cultivar appeared to be controlled by genes that displayed additive effects, dominance in the direction of low dormancy andExpand
  • 11