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- Publications
- Influence
Effect of Streptozotocin Diabetes on Selected Enzymatic Activities in Rat Urine
- M. D. Kuwahara, S. A. Lyons, P. D. Rosenblit, R. Metzger
- Chemistry, Medicine
- Proceedings of the Society for Experimental…
- 1 November 1976
Summary The 24-hr urine collected from streptozotocin-diabetic rats contained activities of acid phosphatase, alkaline phosphatase, N-acetyl-β-D-glucosaminidase, α-L-fu-cosidase, β-D-galactosidase,… Expand
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
- M. D. Kuwahara, S. Sparber
- Biology, Medicine
- Science
- 22 May 1981
Fetal chicks were made opiate-dependent by injections of N-desmethyl-1-alpha-acetylmethadol into the chorioallantois on day 3 of embryogenesis. The injections had no effect on subsequent… Expand
Behavioral consequences of embryonic or early postnatal exposure to l-alpha-noracetylmethadol (NLAAM) in the domestic chicken.
- M. D. Kuwahara, S. Sparber
- Biology, Medicine
- Neurobehavioral toxicology and teratology
- 1 May 1982
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
- M. D. Kuwahara, S. Sparber
- Medicine
- Life sciences
- 31 January 1983
We have used the developing chicken to determine if ornithine decarboxylase (ODC) activity is altered in fetuses chronically exposed to the opiate N-desmethyl-l-alpha-acetylmethadol (NLAAM) or… Expand
Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.
- M. D. Kuwahara, S. Sparber
- Biology, Medicine
- Developmental pharmacology and therapeutics
- 1981
Injection of l-alpha-noracetylmethadol (NLAAM), the active des-methyl metabolite of l-alpha-acetylmethadol, into chicken eggs on the 3rd day of embryonic development produced no deficits in body or… Expand
Spin-label studies on rat liver and heart plasma membranes: Do probe-probe interactions interfere with the measurement of membrane properties?
- R. Sauerheber, L. Gordon, R. Crosland, M. D. Kuwahara
- Chemistry, Medicine
- The Journal of Membrane Biology
- 24 February 1977
SummaryThe structures of purified rat liver and heart plasma membranes were studied with the 5-nitroxide stearic acid spin probe,I(12, 3). ESR spectra were recorded with a 50 gauss field sweep, and… Expand
TOLERANCE AS THE ONLY SIGN OF WITHDRAWAL IN OPIATE DEPENDENT CHICK FETUSES
- S. Sparber, M. D. Kuwahara
- Medicine
- 1981
Tolerance is not evident in opiate-dependent chick fetuses unless they are first treated with a dose of naloxone (Nx) which doesn't block the acute depressant action of 1-α-noracetylmethadol (NLAAM)… Expand