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Distributed reactivity model for sorption by soils and sediments. 15. High-concentration co-contaminant effects on phenanthrene sorption and desorption.
Soil and sediment materials having organic matter matrixes of different geochemical character were examined with respect to their sorption and desorption of phenanthrene in the presence of… Expand
Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes
The American Chemical Society (ACS) Green Chemistry Institute (GCI) Pharmaceutical Roundtable conducted a study to elucidate the value of continuous processing, which had been defined as a key… Expand
A Distributed Reactivity Model for Sorption by Soils and Sediments. 12. Effects of Subcritical Water Extraction and Alterations of Soil Organic Matter on Sorption Equilibria
Subcritical water extraction was used as a tool to remove the carboxylic, aliphatic, and carbohydrate types of organic carbon from a humic soil. The rates and extents of soil organic carbon removal… Expand
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20-21, 2014 Continuous Manufacturing Symposium.
- I. Baxendale, R. Braatz, +5 authors A. Florence
- Computer Science, Medicine
- Journal of pharmaceutical sciences
- 1 March 2015
This whitepaper highlights current challenges and opportunities associated with continuous synthesis, workup, and crystallization of active pharmaceutical ingredients (drug substances). Expand
Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing.
- C. L. Burcham, A. Florence, M. D. Johnson
- Business, Medicine
- Annual review of chemical and biomolecular…
- 7 June 2018
The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by… Expand
Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.
- S. Tsukanov, M. D. Johnson, +5 authors J. N. Johnston
- Chemistry, Medicine
- Organic process research & development
- 1 February 2016
A stereoselective aza-Henry reaction between an arylnitromethane and Boc-protected aryl aldimine using a homogeneous Brønsted acid-base catalyst was translated from batch format to an automated… Expand
Development of a Commercial Flow Barbier Process for a Pharmaceutical Intermediate
A flow Barbier process was developed to produce a key intermediate in the edivoxetine·HCl registered sequence. The control strategy was developed based on a critical understanding of integrated… Expand
A Low-Cost, High-Performance System for Fluorescence Lateral Flow Assays
We demonstrate a fluorescence lateral flow system that has excellent sensitivity and wide dynamic range. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters… Expand
Development of Safe and Scalable Continuous-Flow Methods for Palladium-Catalyzed Aerobic Oxidation Reactions.
- Xuan Ye, M. D. Johnson, T. Diao, M. Yates, S. Stahl
- Chemistry, Medicine
- Green chemistry : an international journal and…
- 1 July 2010
The synthetic scope and utility of Pd-catalyzed aerobic oxidation reactions has advanced significantly over the past decade, and these reactions have potential to address important green-chemistry… Expand
Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions
Continuous-flow technology is devised and implemented for manufacture of a drug candidate in clinical trials. Go with the flow in drug manufacturing Although many commodity chemicals are manufactured… Expand