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Ligand-Independent Activation of Vascular Endothelial Growth Factor Receptor 2 by Fluid Shear Stress Regulates Activation of Endothelial Nitric Oxide Synthase
Abstract— Fluid shear stress generated by blood flowing over the endothelium is a major determinant of arterial tone, vascular remodeling, and atherogenesis. Nitric oxide (NO) produced by endothelialExpand
Separating Fluid Shear Stress from Acceleration during Vibrations In Vitro: Identification of Mechanical Signals Modulating the Cellular Response
The identification of the physical mechanism(s) by which cells can sense vibrations requires the determination of the cellular mechanical environment. Here, we quantified vibration-induced fluidExpand
L-arginine-induced conducted signals alter upstream arteriolar responsivity to L-arginine.
Our purpose was to determine whether L-arginine was involved in vascular communication between downstream and upstream locations within a defined microvascular region. Arteriolar diameter wasExpand
Energy optimization and bifurcation angles in the microcirculation.
Our purpose was to examine the relationship between bifurcation angle and energy optimization in the arteriolar microcirculation. We measured bifurcation angles and diameters for sequential branchesExpand
Arteriolar bifurcation angles vary with position and when flow is changed.
Flow distribution at microvascular bifurcations is influenced by the geometry of the bifurcation region, an area which also is altered pathologically. Bifurcation geometry was measured by in vivoExpand
Biofluid mechanics : an introduction to fluid mechanics, macrocirculation, and microcirculation
Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation shows how fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement, renal transport among other specialty circulations. Expand
Conducted signals within arteriolar networks initiated by bioactive amino acids.
  • M. D. Frame
  • Chemistry, Medicine
  • American journal of physiology. Heart and…
  • 1 March 1999
Our purpose was to determine the specificity of l-arginine (l-Arg)-induced conducted signals for intra- vs. extracellular actions ofl-Arg. Diameter and red blood cell velocities were measured forExpand
Terminal Arteriolar Network Structure/Function and Plasma Cytokine Levels in db/db and ob/ob Mouse Skeletal Muscle
Please cite this paper as: Georgi, Vigilance, Dewar, and Frame (2011). Terminal Arteriolar Network Structure/Function and Plasma Cytokine Levels in db/db and ob/ob Mouse Skeletal Muscle.Expand
Network Vascular Communication Initiated by Increases in Tissue Adenosine
Vascular communication of vasomotor signals appears to coordinate the distribution of tissue blood flow. This study was performed to determine whether elevated tissue concentrations of adenosine orExpand
Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.
Our purpose was to evaluate hyporesponsivity to nitric oxide (NO)-induced dilation in small arterioles during nitrate tolerance. An Alza osmotic pump was implanted in the left flank of adult rats (nExpand