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Store-Operated Ca2 + Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
The findings indicate that SOCE contributes to melanoma progression, and therefore may be a new potential target for treatment of melanoma, irrespective of whether or not Braf mutation is present. Expand
The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells
- J. Yoshii, H. Yoshiji, +11 authors H. Fukui
- Biology, Medicine
- International journal of cancer
- 15 December 2001
Trientine dihydrochloride (trientine) is used in clinical practice as an alternative copper (Cu)‐chelating agent for patients with Wilson's disease of penicillamine intolerance and may be an effective new strategy for future HCC therapy. Expand
Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands.
Results suggest that activation of EGFR signaling contributes to the elevated levels of COX-2 found in the oral mucosa of smokers, and strengthen the rationale for determining whether inhibitors of COx-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract. Expand
Exchange protein directly activated by cyclic AMP increases melanoma cell migration by a Ca2+-dependent mechanism.
The findings reveal that Epac is a potential target for the suppression of melanoma cell migration, and, thus, the development of metastasis, and a role for Epac1 in melanoma metastasis is suggested. Expand
Tobacco smoke induces CYP1B1 in the aerodigestive tract.
A role for CYP1B1 in TS-induced carcinogenesis in the aerodigestive tract is supported, consistent with prior evidence that polycyclic aromatic hydrocarbons, known ligands of the AhR, stimulate CYP 1B1 transcription by an XRE-dependent mechanism. Expand
Expression of metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in schistosomal portal fibrosis.
- D. Gomez, M. D. De Lorenzo, D. Alonso, Z. Andrade
- Medicine, Biology
- The American journal of tropical medicine and…
- 1 July 1999
Findings are consistent with the concept that matrix degradation in recent and old fibroses, in addition to differing at the ultrastructural level, also differs in immunohistochemical expression of metalloproteinases and their inhibitors. Expand
Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity
The similarly regulated genes and pathways in AC5 KO and CR mice, particularly related to the metabolic phenotype, suggest a unified theory for longevity and stress resistance. Expand
Epac1 promotes melanoma metastasis via modification of heparan sulfate
- E. Baljinnyam, M. Umemura, +4 authors K. Iwatsubo
- Chemistry, Medicine
- Pigment cell & melanoma research
- 1 August 2011
It is found that, in human melanoma tissue microarray, protein expression of Epac1 was higher in metastatic melanoma than in primary melanoma, and expressions of NDST‐1, N‐sulfated HS, and cell migration in various melanoma cell lines suggest that Epac 1 plays a critical role in melanoma metastasis presumably because of modification of HS. Expand
Nafoxidine modulates the expression of matrix-metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in endothelial cells.
It is postulated that nafoxidine induces an increase in TIMP-1, which has antiangiogenic activity in the late stages of tube formation, independent of its capacity to inhibit MMPs. Expand
Gβγ subunits inhibit Epac-induced melanoma cell migration
There is crosstalk of Ca 2+ signaling between G βγ and Epac in melanoma, which plays a role in regulation of cell migration and the mechanism by which Gβγ inhibits Epac-inducedCa 2+ elevation was explored. Expand