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Effect of sympathomimetic amines on the blocking action of guanethidine, bretylium and xylocholine.
- M. D. Day
- Biology, ChemistryBritish journal of pharmacology and chemotherapy
- 1 April 1962
It is discussed that the sympathomimetic amines which antagonize the adrenergic neurone blocking drugs are competing with these substances for the same receptor sites.
The lack of crossed tachyphylaxis between tyramine and some other indirectly acting sympathomimetic amines.
- M. D. Day
- Chemistry, MedicineBritish journal of pharmacology and chemotherapy
- 1 August 1967
CARDIOVASCULAR EFFECTS OF β‐ADRENORECEPTOR BLOCKING AGENTS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION IN CONSCIOUS NORMOTENSIVE CATS
Seven β‐adrenoreceptor antagonists produced sustained falls in blood pressure and heart rate after intracerebroventricular (icv) administration in conscious, normotensive cats.
CARDIOVASCULAR EFFECTS OF DOPAMINE AFTER CENTRAL ADMINISTRATION INTO CONSCIOUS CATS
Dopamine administered intracerebroventricularly to a group of 10 conscious normotensive cats caused dose‐related increases in blood pressure and heart rate and injection of dopamine into the cisterna magna produced predominantly depressant effects on the cardiovascular system except with a higher dose which induced biphasic responses.
Tissue levels of several radiolabelled beta-adrenoceptor antagonists after intravenous administration in rats.
- J. A. Street, B. Hemsworth, A. Roach, M. D. Day
- Biology, MedicineArchives internationales de pharmacodynamie et de…
- 1 February 1979
Results are consistent with the hypothesis that a central action may contribute to the antihypertensive effect of beta-adrenoceptor antagonists and significantly lower in the 2 and 3 week pretreated rats compared to the control animals.
A HYPOTHESIS FOR THE MODE OF ACTION OF α‐METHYLDOPA IN RELIEVING HYPERTENSION
There is evidence that α‐methyldopa can serve as the precursor of α‐methylnoradrenaline in the body and some loss of responsiveness to sympathetic nerve stimulation which can explain the lowering of blood pressure in hypertensive patients.
CARDIOVASCULAR EFFECTS OF CARBACHOL AND OTHER CHOLINOMIMETICS ADMINISTERED INTO THE CEREBRAL VENTRICLES OF CONSCIOUS CATS
1. The cholinomimetic substances acetylcholine, nicotine, tetramethylammonium chloride and carbachol were infused intracerebroventricularly (i.c.v.) into conscious, normotensive cats and their…
Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats.
The results are discussed in the light of the mode of action of beta-adrenoceptor stimulants and beta-adsenoceptor blocking agents in the treatment of hypertension.
CENTRAL α‐ AND β‐ADRENOCEPTORS MODIFYING ARTERIAL BLOOD PRESSURE AND HEART RATE IN CONSCIOUS CATS
The results are discussed in the light of the mode of action of β‐adrenoceptor stimulants and β-adrenOceptor blocking agents in the treatment of hypertension.