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Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators
- M. D. Berry
- BiologyJournal of neurochemistry
- 1 July 2004
Previous studies showing responses to physiologically relevant concentrations of trace amines are reviewed, along with those showing a reciprocal relationship between trace amine levels and fluctuations in basal monoaminergic tone, and it is hypothesized that the traceAmines function as endogenous neuromodulators of classical monoamine neurotransmitters.
Apoptotic signaling cascades
Trace Amines and Their Receptors
In the brain, TAAR1 acts as a rheostat of dopaminergic, glutamatergic, and serotonergic neurotransmission and has been identified as a novel therapeutic target for schizophrenia, depression, and addiction, and in the periphery,TAAR1 regulates nutrient-induced hormone secretion, suggesting its potential as a Novel therapeutic targets for diabetes and obesity.
The functional role of monoamine oxidases A and B in the mammalian central nervous system
Pharmacology of human trace amine‐associated receptors: Therapeutic opportunities and challenges☆
Aromaticl-amino acid decarboxylase: A neglected and misunderstood enzyme
Advances made during the past 10 years are described, demonstrating that AADC is regulated both pre- and post-translation, including the intriguing possibility of A ADC gene regulation being linked to that of factors thought to have a role in apoptosis and its prevention.
Inhibition of monoamine oxidase-B by (-)-deprenyl potentiates neuronal responses to dopamine agonists but does not inhibit dopamine catabolism in the rat striatum.
- I. Paterson, A. Juorio, M. D. Berry, M. Zhu
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 September 1991
In electrophysiological studies, single caudate neuron responses to iontophoretically applied (-)-apomorphine and (+/-)-2-(N-phenethyl-N-propyl) amino-5-hydroxytetralin were potentiated by intracarotid injections of PE and i.p. injections of (-)-deprenyl.
Glyceraldehyde‐3‐phosphate dehydrogenase and apoptosis
The evidence implicating GAPDH in the initiation of one or more apoptotic cascades is summarized and the possible functions of GAPDh in the nucleus which could result in the Initiation of apoptosis are discussed.
The potential of trace amines and their receptors for treating neurological and psychiatric diseases.
- M. D. Berry
- BiologyReviews on recent clinical trials
The aim of the current article is to review the previous studies linking trace amines to human pathology in the context of the recently discovered trace amine receptors and evidence of the existence of Trace amine receptor polymorphisms and mutations associated with such disorders.