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Role of macrophage targeting in the antitumor activity of trabectedin.
It is demonstrated that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusively in mononuclear phagocytes, and this unexpected property may be exploited in different therapeutic strategies. Expand
Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance
Changes in P-gp mRNA levels occur in limbic areas after both acute and chronic epileptic activity, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy. Expand
Bortezomib-induced peripheral neurotoxicity: A neurophysiological and pathological study in the rat
At the maximum tolerated dose bortezomib induced a significant reduction in SNCV, with a complete recovery at the end of the follow-up period, which is relevant to the neuropathy induced by bortzomib in the treatment of human malignancies. Expand
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.
The findings that G1 phase cells are hypersensitive and that NER-deficient cells are resistant to ET-743 indicate that the mode of action of ET- 743 is unique and different from that of other DNA-interacting drugs. Expand
A Review of Trabectedin (ET-743): A Unique Mechanism of Action
The promising data on the combination of trabectedin with other anticancer agents, observed in preclinical systems, have prompted several clinical studies that are currently ongoing, and one of these combinations was recently authorized by the European Commission for the treatment of patients with relapsed platinum-sensitive ovarian cancer. Expand
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
- E. Salvati, C. Leonetti, +14 authors A. Biroccio
- Medicine, Biology
- The Journal of clinical investigation
- 1 November 2007
It is shown that RHPS4 triggers a rapid and potent DNA damage response at telomeres in human transformed fibroblasts and melanoma cells, and the key role of telomere-protective factors TRF2 and POT1 in response to this anti-telomere strategy is revealed. Expand
Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer.
Some genes involved in EMT were associated to overall or progression free survival, suggesting EMT as vital to the resistance mechanisms. Expand
Targeting triple negative breast cancer: is p53 the answer?
Within this review, several agents with potential activity against aberrant p53 signaling have been considered, as a novel approach to finding an effective targeted therapy for this aggressive breast cancer subtype. Expand
Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study.
Trabectedin was associated with antitumour activity in this series of patients with myxoid liposarcoma, and the noted patterns of tumour response were such that tissue density changes occurred before tumour shrinkage in several patients. Expand
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
The inactivation of MMR increased the mutational burden and led to dynamic mutational profiles, which resulted in the persistent renewal of neoantigens in vitro and in vivo, whereas MMR-proficient cells exhibited stable mutational load and neoantigen profiles over time. Expand