Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids.
- M. D’hooghe, Karen Mollet, Rob De Vreese, T. Jonckers, G. Dams, N. de Kimpe
- Chemistry, BiologyJournal of Medicinal Chemistry
- 17 May 2012
The identification of eight purine-β-lactam hybrids and two Purine-aminopropanol hybrids as promising lead structures is made.
Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.
Long-term follow up of glatiramer acetate compassionate use in Belgium.
- C. Sindic, P. Seeldrayers, M. A. van der Tool
- Medicine, PsychologyActa Neurologica Belgica
- 1 June 2005
The sustained efficacy of glatiramer acetate in reducing the disease progression in patients with relapsing-remitting multiple sclerosis treated in day-to-day clinical practice is confirmed.
Quinoline-based antimalarial hybrid compounds.
Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks.
- Nicola Piens, K. Van Hecke, D. Vogt, M. D’hooghe
- Chemistry, BiologyOrganic and biomolecular chemistry
- 7 June 2017
The Co2(CO)8-catalyzed carbonylation of different classes of non-activated aziridines with diverse substitution patterns was investigated and resulted in the regio- and stereospecific synthesis of 24 novel β-lactam target structures in high yields on a multigram scale.
Biocatalytic production of novel glycolipids with cellodextrin phosphorylase.
Converting bulk sugars into prebiotics: semi-rational design of a transglucosylase with controlled selectivity.
This work applied semi-rational mutagenesis and low-throughput screening, which resulted in a double mutant (L341I_Q345S) with a selectivity of 95% for kojibiose, and an efficient and scalable production process with a yield of 74% was established.
Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models
- Yves Depetter, Silke Geurs, O. De Wever
- Biology, ChemistryInternational Journal of Cancer
- 1 August 2019
The results suggest that selective HDAC6 inhibitors may fall short as potential single agent anti‐cancer drugs and prove that many previous data regarding this promising class of compounds need to be interpreted with great care due to their use in high concentrations resulting in low selectivity and potential off‐target effects.