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Cells of the human intestinal tract mapped across space and time
This work reveals the presence of BEST4+ absorptive cells throughout the human intestinal tract, demonstrating the existence of this cell type beyond the colon for the first time, and identifies key cell players across multiple cell lineages driving secondary lymphoid tissue formation in early human development.
Identification by Mutational Analysis of Amino Acid Residues Essential in the Chaperone Function of Calreticulin*
- V. Martin, J. Groenendyk, M. Michalak
- Biology, ChemistryJournal of Biological Chemistry
- 27 January 2006
Although the Glu239, Asp241, and Glu243 mutants did not bind ERp57 efficiently, they fully restored bradykinin-dependent Ca2+ release in crt-/- cells, which indicates that binding of ERp 57 to calreticulin may not be critical for the chaperone function of cal reticulin with respect to the bradykinsin receptor.
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an…
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
In vitro that downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively, provides a platform for future development of treatments for a range of common endometrial disorders including endometriosis and carcinoma.
Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin*
It is concluded that mutation of a single amino acid residue in calreticulin has devastating consequences for its chaperone function, indicating that mutations in chaperones may play a significant role in protein folding disorders.
alpha1-microglobulin as a marker of proximal tubular damage in urinary tract infection in children.
- M. Mantur, H. Kemona, M. Dąbrowska, J. Dąbrowska, S. Sobolewski, J. Prokopowicz
- Medicine, BiologyClinical nephrology
- 1 April 2000
The results indicate the usefulness of the urinary alpha-microglobulin/creatinine ratio as a marker of proximal kidney tubule damage in children with E. coli and Proteus sp.
Bioactive substances of garlic and their role in dietoprophylaxis and dietotherapy.
- F. Świderski, M. Dąbrowska, A. Rusaczonek, B. Waszkiewicz-Robak
- Chemistry, MedicineRoczniki Panstwowego Zakladu Higieny
This work has aimed to characterise the most important bioactive substances of garlic, its preparations and describe in detail the role of garlic in dietoprophylaxis and dietotherapy.
A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche
A transcriptional and spatial lung atlas with multiple novel cell types that allows for the study of specific tissue microenvironments such as the newly defined gland-associated lymphoid niche (GALN).