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Identification by Mutational Analysis of Amino Acid Residues Essential in the Chaperone Function of Calreticulin*
Although the Glu239, Asp241, and Glu243 mutants did not bind ERp57 efficiently, they fully restored bradykinin-dependent Ca2+ release in crt-/- cells, which indicates that binding of ERp 57 to calreticulin may not be critical for the chaperone function of cal reticulin with respect to the bradykinsin receptor. Expand
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such anExpand
Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin*
It is concluded that mutation of a single amino acid residue in calreticulin has devastating consequences for its chaperone function, indicating that mutations in chaperones may play a significant role in protein folding disorders. Expand
alpha1-microglobulin as a marker of proximal tubular damage in urinary tract infection in children.
The results indicate the usefulness of the urinary alpha-microglobulin/creatinine ratio as a marker of proximal kidney tubule damage in children with E. coli and Proteus sp. Expand
Bioactive substances of garlic and their role in dietoprophylaxis and dietotherapy.
This work has aimed to characterise the most important bioactive substances of garlic, its preparations and describe in detail the role of garlic in dietoprophylaxis and dietotherapy. Expand
Assessment of the chromatographic lipophilicity of eight cephalosporins on different stationary phases
A comprehensive chromatographic investigation into the retention of the analyzed cephalosporins revealed a similar behavior on RP‐18, RP‐8 and –CN stationary phases, which revealed that RM0 and PC1/RM are relevant lipophilicity parameters and theRP‐8, –CN and RP‐ 18 plates are appropriate stationary phases for lipophILicity investigation, whereas computational approaches still cannot fully replace experimentation. Expand
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
In vitro, it is shown that whilst ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions, and compensates for immune escape mutations that impair infectivity. Expand
Analytical approaches to determination of carnitine in biological materials, foods and dietary supplements.
The analytical procedures presented in this review have been validated in terms of basic parameters (linearity, limit of detection,limit of quantitation, sensitivity, accuracy, and precision). Expand
Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: a review.
Separation, optical, electrochemical and calculation methods which were developed and used for determination of lipophilicity non-steroidal anti-inflammatory agents and cephalosporin antibiotics in drugs and biological materials, have been reviewed. Expand
Lipophilicity study of eight cephalosporins by reversed-phase thin-layer chromatographic method.
The received results demonstrate that RP-TLC may be a good alternative technique for analytics in describing the lipophilic nature of investigated cephalosporins as well as the activity. Expand