• Publications
  • Influence
Pathogenesis of group A streptococcal infections.
  • M. Cunningham
  • Biology, Medicine
    Clinical microbiology reviews
  • 1 July 2000
TLDR
Group A streptococci are model extracellular gram-positive pathogens responsible for pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis, and an emerging theme is the dichotomy between skin and throat strains in their epidemiology and genetic makeup.
Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea
TLDR
Chorea monoclonal antibodies showed specificity for mammalian lysoganglioside and N-acetyl-β-D-glucosamine (GlcNAc), the dominant epitope of the group A streptococcal (GAS) carbohydrate, which will lead to a better understanding of other antibody-mediated neurological disorders.
Acute rheumatic fever and rheumatic heart disease
TLDR
Progress in developing group A streptococcal vaccines and an increased focus on the lived experience of those with RHD and the need to improve quality of life give cause for optimism that progress will be made against this neglected disease.
Pathogenesis of group A streptococcal infections and their sequelae.
  • M. Cunningham
  • Medicine
    Advances in experimental medicine and biology
  • 2008
Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference.
TLDR
A consensus statement is presented proposing recommendations for the diagnostic evaluation of youth presenting with PANS and the most urgently needed studies in this field are set forth.
Mimicry and Antibody-Mediated Cell Signaling in Autoimmune Myocarditis1
TLDR
This work shows that autoantibodies to CM in anti-CM sera and mAbs derived from experimental autoimmune myocarditis targeted the heart cell surface and induced Ab-mediated cAMP-dependent protein kinase A activity.
Mimicry in Recognition of Cardiac Myosin Peptides by Heart-Intralesional T Cell Clones from Rheumatic Heart Disease1
TLDR
This is the first study showing the cellular response by human heart-infiltrating T cells against cardiac myosin epitopes in RHD patients, and strengthens its role as one of the major autoantigens involved in rheumatic heart lesions.
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
TLDR
This new animal model translates directly to human disease and led to discover autoantibodies targeted against dopamine D1 and D2 receptors in the rat model as well as in SC and other streptococcal-related neuropsychiatric disorders.
Usefulness of immunosuppression for giant cell myocarditis.
TLDR
This prospective study of immunosuppression for GCM confirms retrospective case reports that such therapy improves long-term survival and can be associated with fatal GCM recurrence, and demonstrates for the first time that there is a risk of recurrent, sometimes fatal, GCM after cessation of immunsuppression.
Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease
TLDR
Evidence for the hypotheses of molecular mimicry and epitope spreading are reviewed and the potential pathogenic mechanisms by which the immune response against the group A streptococcus attacks the rheumatic valve leading to chronic rhematic heart disease are unraveled.
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