• Publications
  • Influence
Pathogenesis of group A streptococcal infections.
  • M. Cunningham
  • Medicine, Biology
  • Clinical microbiology reviews
  • 1 July 2000
Group A streptococci are model extracellular gram-positive pathogens responsible for pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of invasive streptococcalExpand
  • 1,579
  • 112
  • Open Access
Acute rheumatic fever and rheumatic heart disease
Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which canExpand
  • 142
  • 12
  • Open Access
Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea
Streptococcus pyogenes–induced acute rheumatic fever (ARF) is one of the best examples of postinfectious autoimmunity due to molecular mimicry between host and pathogen. Sydenham chorea is the majorExpand
  • 354
  • 11
  • Open Access
Mimicry and Antibody-Mediated Cell Signaling in Autoimmune Myocarditis1
The mechanisms by which autoantibodies against cardiac myosin (CM) may lead to heart dysfunction is unknown. We show that autoantibodies to CM in anti-CM sera and mAbs derived from experimentalExpand
  • 114
  • 9
  • Open Access
Pathogenesis of group A streptococcal infections and their sequelae.
  • M. Cunningham
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 2008
  • 156
  • 8
Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference.
On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians and researchers from complementaryExpand
  • 118
  • 8
  • Open Access
Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin.
Anti-streptococcal antibodies cross-reactive with N-acetyl-betaD-glucosamine (GlcNAc) and myosin are present in the sera of patients with rheumatic fever (RF). However, their role in tissue injury isExpand
  • 177
  • 7
  • Open Access
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham choreaExpand
  • 122
  • 7
  • Open Access
Mimicry in Recognition of Cardiac Myosin Peptides by Heart-Intralesional T Cell Clones from Rheumatic Heart Disease1
Molecular mimicry between Streptococcus pyogenes Ags and human proteins has been considered as a mechanism leading to autoimmune reactions in rheumatic fever and rheumatic heart disease (RHD).Expand
  • 129
  • 7
  • Open Access
Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds.
Diabetic foot wounds present a great challenge to wound care practitioners. The objective of this pilot study was to determine whether vacuum-assisted closure (V.A.C.) therapy would afford quickerExpand
  • 295
  • 6