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Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics
- G. Filardo, H. Madry, M. Jelić, A. Roffi, M. Cucchiarini, E. Kon
- Knee Surgery, Sports Traumatology, Arthroscopy
- 11 January 2013
Despite the growing interest in this biological approach for cartilage regeneration, knowledge on this topic is still preliminary, as shown by the prevalence of preclinical studies and the presence of low-quality clinical studies. Expand
Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I)
The data indicate that allogeneic chondrocytes, transfected by a nonviral method and cultured in alginate, are able to secrete biologically relevant amounts of IGF-I over a prolonged period of time in vitro and suggest that therapeutic growth factor gene delivery using encapsulated and transplanted genetically modified chondROcytes may be applicable to sites of focal articular cartilage damage. Expand
Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model.
The lack of correlation suggests that articular cartilage repair and subchondral bone reconstitution proceed at a different pace and that the advancement of the subchONDral bone plate is not responsible for the diminished articularcartilage repair in this model. Expand
Small-Diameter Awls Improve Articular Cartilage Repair After Microfracture Treatment in a Translational Animal Model
- P. Orth, Julia Duffner, D. Zurakowski, M. Cucchiarini, H. Madry
- The American journal of sports medicine
- 1 January 2016
Small-diameter microfracture awls improve articular cartilage repair in the translational sheep model more effectively than do larger awls and support the use of small microfractions for the surgical treatment of cartilage defects. Expand
Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C.
The data show that the number of IFN-gamma-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection. Expand
A vision on the future of articular cartilage repair.
The current state of the art in the field of cell therapy for cartilage repair is described to help define a procedure adapted to the clinical situation for upcoming translation in the patient. Expand
Tissue engineering for articular cartilage repair--the state of the art.
The complexity of this problem suggests that a multidisciplinary approach - combining a clinical perspective with expertise in cell biology, biomechanics, biomaterials science and high-throughput analysis will likely be necessary to address the challenge of developing functional cartilage replacements. Expand
Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects
- Mona Eldracher, P. Orth, M. Cucchiarini, D. Pape, H. Madry
- The American journal of sports medicine
- 28 August 2014
Small subchondral drill holes that reflect the physiological trabecular distance improve osteochondral repair in a translational model more effectively than larger drill holes. Expand
Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid‐mediated gene transfer in a gel suspension delivery system
- H. Madry, M. Cucchiarini, +4 authors S. Trippel
- Chemistry, Medicine
- The journal of gene medicine
- 1 June 2003
The hypothesis that a recombinant gene can be delivered to sites of cartilage damage in vivo using chondrocytes transfected by a lipid‐mediated gene transfer method is tested. Expand
Current perspectives in stem cell research for knee cartilage repair
- P. Orth, A. Rey-Rico, J. K. Venkatesan, H. Madry, M. Cucchiarini
- Stem cells and cloning : advances and…
- 16 January 2014
Various sources of progenitor cells are now available, originating from adult tissues but also from embryonic or reprogrammed tissues, most of which have already been evaluated for their chondrogenic potential in culture and for their reparative properties in vivo upon implantation in relevant animal models of cartilage lesions. Expand