M. Crumpton

Publications220
h-index56
Citations8,571
Highly Influential Citations82
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Preparation and characterization of the plasma membrane of pig lymphocytes.
TLDR
It is concluded that the preparation represents the plasma membrane of small lymphocytes, which was isolated from minced pig mesenteric lymph node by differential centrifugation and by centrifuging through a sucrose density gradient and its properties were similar to those of the lymphocyte plasma membrane.
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Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain.
TLDR
It is suggested that the TfR/zeta complex is responsible for transducing the T fR-induced signals, and that it could serve to amplify signals delivered by Ag binding to the TCR.
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The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes
TLDR
A digitonin-based solubilization procedure is used to explore the possibility that 40% of the cell-surface CD2 molecules can be specifically co-precipitated in association with the Ti–CD3 complex and suggest that these T-lymphocyte cell- surface structures are physically associated.
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Amino acid sequence analysis of the annexin super-gene family of proteins.
TLDR
The structure confirms most of the predictions and shows the power of techniques for the determination of tertiary structural information from the amino acid sequences of an aligned protein family.
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Molecular structure of human histocompatibility antigens: the HLA‐C series
TLDR
The results of various studies suggest that the Hla‐CW2 antigen is expressed to a lower extent than the HLA‐A or B antigens and that essentially all of the β2 m of the BRI 8 plasma membrane is associated with the H LA‐A, B and C alloantigenic polypeptides.
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A COMPARISON OF THE CONFORMATION OF SPERM WHALE METMYOGLOBIN WITH THAT OF APOMYOGLOBIN.
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Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.
CD2 (T11, sheep erythrocyte receptor) is a surface antigen of the human T-lymphocyte lineage. cDNA clones encoding CD2 have been isolated by using the purified, denatured CD2 to raise a rat…
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A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation.
TLDR
A novel PKC assay system using streptolysin-O-permeabilized T cells is established and data are consistent with the presence of more than one G-protein-mediated pathway of PKC regulation in T cells.
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AMINO ACID COMPOSITIONS OF HUMAN AND RABBIT GAMMA-GLOBULINS AND OF THE FRAGMENTS PRODUCED BY REDUCTION.
Heide, K., Haupt, H. & Schmidtberger, R. (1959). Behringwerk-Mitteilungen, 37, 29. Johansen, P. G., Marshall, R. D. & Neuberger, A. (1960). Biochem. J. 77, 239. Kabat, E. A. & Mayer, M. M. (1961).…
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The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes
TLDR
The results suggest that PHA triggers T lymphocytes by interacting with the carbohydrate moieties of Ti and imply that T lymphocyte proliferation can be stimulated by mitogens via at least two different cell surface molecules (Ti and T3).
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