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Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study.
TLDR
Bivalent vaccination has led to a startling reduction in vaccine and cross-protective HPV types 7 years after vaccination, and should be considered in cost-effectiveness models informing vaccine choice and models to shape the future of cervical screening programmes. Expand
Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland
TLDR
One of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level is shown, which is very encouraging for countries that have achieved high HPV vaccine uptake. Expand
Profiling Cytochrome P450 Expression in Ovarian Cancer: Identification of Prognostic Markers
TLDR
Several P450s show increased expression in ovarian cancer and this provides the basis for developing P450-based therapeutics in ovary cancer. Expand
HPV testing as an adjunct to cytology in the follow up of women treated for cervical intraepithelial neoplasia
TLDR
Evaluated human papillomavirus testing in combination with cytology in the follow up of treated women shows positive results for HPV and cytology testing for HPV infection in women treated with HPV. Expand
Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled
TLDR
The VIVIANE study of the HPV 16/18 AS04-adjuvanted vaccine in adult women after 7 years of follow-up continues to protect against infections, cytological abnormalities, and lesions associated with HPV 15/18 and CIN1+ irrespective of HPV type, and infection with non-vaccine types HPV 31 and HPV 45. Expand
Factors associated with psychological distress following colposcopy among women with low‐grade abnormal cervical cytology: a prospective study within the Trial Of Management of Borderline and Other
TLDR
This work investigated psychological distress following colposcopy and related procedures in women with low‐grade abnormal cervical cytology and associated investigations and treatment. Expand
Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study
TLDR
Estimated at the means, the incremental cost effectiveness ratios indicated that immediate treatment was dominated by the other two management methods, although it did offer the lowest cost per case of cervical intraepithelial neoplasia detected and treated. Expand
Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised
TLDR
In women older than 25 years, the HPV 16/18 vaccine is efficacious against infections and cervical abnormalities associated with the vaccine types, as well as infections with the non-vaccine HPV types 31 and 45. Expand
Docetaxel-carboplatin as first line chemotherapy for epithelial ovarian cancer
TLDR
The maximum tolerated dose was reached in cohorts 4 and 5, and the dose limiting toxicities were myelosuppression and diarrhoea, and a randomized trial comparing this regimen with carboplatin-paclitaxel has just completed recruitment. Expand
Fertility and pregnancy outcome following large loop excision of the cervical transformation zone
Objective To determine if large loop excision of the transformation zone affects subsequent fertility and pregnancy outcome.
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