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Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.
PURPOSE The retinoid response is mediated by nuclear receptors, including retinoic acid receptors (RARs) and retinoid "X" receptors (RXRs). All-trans retinoic acid (RA) binds only RARs, while 9-cisExpand
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A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested.
We compared ten methods for extraction of DNA from whole blood. Nine methods require incubation with either enzymes or treatment of organic solvents or both. The 'Rapid Method' (RM) (Method 10)Expand
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Electrophoresis of acid phosphohydrolase isozymes on Cellogel.
Abstract Methods are presented for the electrophoresis and detection of various acid phosphohydrolases on Cellogel. Isozymes of acid DNase, RNase, 3′-phosphodiesterase, and nonspecificExpand
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Protein sequences bound to mineral surfaces persist into deep time
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving theExpand
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A positive zymogram method for ribonuclease.
Abstract We have developed a rapid, sensitive, and specific zymogram for detecting ribonuclease (RNase). The method makes use of an agarose gel containing the small substrate UpA [uridylyl (3′ →Expand
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Tissue specificity of human phosphodiesterase. I. Blood serum.
Human blood serum was found to contain two enzymes which hydrolyze various phosphate diester and phosphonate ester bonds. The enzymes were isolated by butanol extraction, ammonium sulfateExpand
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The synthesis of 4-methylumbelliferyl phenylphosphonate and its used in an improved method for the zymogram analysis of phosphodiesterase I.
The 4-methylumbelliferyl analog of p-nitrophenyl phenylphosphonate was prepared and its cleavage by different phosphohydrolases was studied. The new compound, 4-methylumbelliferyl phenylphosphonate,Expand
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Bovine enterovirus-1: characterization, replication and cytopathogenic effects.
Summary The biological parameters of a bovine picornavirus, bovine enterovirus-1, are described. The virus is shown to have a rapid growth cycle and to be stable over an extended period at 56 °C andExpand
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Anionic groups in basement membranes
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