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Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity.
Cell fractionation according to lineage depletion and ALDH activity provides a viable and prospective purification of HSCs on the basis of cell function rather than cell surface phenotype. Expand
Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.
Cell selection based on ALDH activity and CD133 expression provides a novel purification of HSCs with long-term repopulating function and may be considered an alternative to CD34 cell selection for stem cell therapies. Expand
Keratan sulphate levels in mucopolysaccharidoses and mucolipidoses
- S. Tomatsu, K. Okamura, +29 authors A. Noguchi
- Journal of Inherited Metabolic Disease
- 1 April 2005
The finding suggests that measurement of KS level provides a new diagnostic biomarker in a wide variety of mucopolysaccharidoses and mucolipidoses in addition to MPS IV, in contrast to the conventional understanding. Expand
Current Role of Radiation Therapy for Multiple Myeloma
Despite the introduction of novel effective agents in the treatment of MM, RT remains a major therapeutic component for the management in 34% of patients, and it effectively provides pain relief while not interfering with successful peripheral blood stem cell collection for ASCT. Expand
Development and Testing of New Screening Method for Keratan Sulfate in Mucopolysaccharidosis IVA
An ELISA-sandwich assay that used a MAb specific to KS indicated that the new assay for blood or urine KS may be suitable for early diagnosis and longitudinal assessment of disease severity in MPS IVA. Expand
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons
- K. Partlow, Junjie Chen, +7 authors Samuel A. Wicldine
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 June 2007
PFC nanoparticles provide an unequivocal and unique signature for stem/progenitor cells, enable spatial cell localization with 19F MRI, and permit quantification and detection of multiple fluorine signatures via 19F MR spectroscopy. Expand
Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart.
- S. Datorre, M. Creer, S. Pogwizd, P. Corr
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 February 1991
Evidence is provided that accumulation of long-chain acylcarnitine occurs very rapidly in ischemic myocardium in vivo, coincident with the development of electrophysiologic alterations leading to malignant arrhythmias as verified using 3-dimensional cardiac mapping procedures. Expand
Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease.
Xenotransplantation experiments in the NOD/SCID/MPSVII mouse represent a powerful approach to both study the in vivo biology of human cells and gather preclinical data regarding treatment approaches for a human disease. Expand
Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial Cells
- P. Kell, M. Creer, K. N. Crown, Karin C Wirsig, J. McHowat
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 December 2003
It is concluded that MAFP augments thrombin-stimulated PAF production by inhibition of PAF catabolism without affecting membrane-associated iPLA2 activity. Expand
First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation.
This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients. Expand