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The role of visual experience in the development of columns in cat visual cortex.
The role of experience in the development of the cerebral cortex has long been controversial. Patterned visual experience in the cat begins when the eyes open about a week after birth. Cortical mapsExpand
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A critical period for long-term potentiation at thalamocortical synapses
IN mammalian development, the refinement of topographical projections from the thalamus to the cortex is thought to arise through an activity-dependent process in which thalamic axons compete forExpand
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Silent Synapses during Development of Thalamocortical Inputs
During development, activity-dependent mechanisms are thought to contribute to the refinement of topographical projections from the thalamus to the cortex. Because activity-dependent increases inExpand
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Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
The regulation of NMDA receptor (NMDAR) subunit composition and expression during development is thought to control the process of thalamocortical afferent innervation, segregation, and plasticity.Expand
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Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the Mouse
Although it is widely accepted that molecular mechanisms play an important role in the initial establishment of retinotopic maps, it has also long been argued that activity-dependent factors act inExpand
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Retinal waves coordinate patterned activity throughout the developing visual system
The morphological and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal activity. However, fundamental features ofExpand
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An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development
Complex neural circuits in the mammalian brain develop through a combination of genetic instruction and activity-dependent refinement. The relative role of these factors and the form of neuronalExpand
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The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons
Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebralExpand
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Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple features of early cortical development. It remains uncertain and controversial,Expand
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Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice
The maturation of retinal ganglion cell (RGC) axon projections in the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) relies on both molecular and activity-dependentExpand
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