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Mapping and Analysis of Chromatin State Dynamics in Nine Human Cell Types
Chromatin profiling has emerged as a powerful means for genome annotation and detection of regulatory activity. Here we map nine chromatin marks across nine cell types to systematically characterizeExpand
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Systematic analysis of chromatin state dynamics in nine human cell types
Chromatin profiling has emerged as a powerful means of genome annotation and detection of regulatory activity. The approach is especially well suited to the characterization of non-coding portions ofExpand
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An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts
BACKGROUND The human intestine is colonized with trillions of microorganisms important to health and disease. There has been an intensive effort to catalog the species and genetic content of thisExpand
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Extensive surface diversity of a commensal microorganism by multiple DNA inversions
The dynamic interactions between a host and its intestinal microflora that lead to commensalism are unclear. Bacteria that colonize the intestinal tract do so despite the development of a specificExpand
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A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont
The Bacteroides are a numerically dominant genus of the human intestinal microbiota. These organisms harbor a rare bacterial pathway for incorporation of exogenous fucose into capsularExpand
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Characterization of the serogroup O11 O-antigen locus of Pseudomonas aeruginosa PA103.
We previously cloned a genomic DNA fragment from the serogroup O11 Pseudomonas aeruginosa strain PA103 that contained all genes necessary for O-antigen synthesis and directed the expression ofExpand
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Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements
BackgroundType VI secretion systems (T6SSs) are contact-dependent antagonistic systems employed by Gram negative bacteria to intoxicate other bacteria or eukaryotic cells. T6SSs were recentlyExpand
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Human Symbionts Use a Host-Like Pathway for Surface Fucosylation
The mammalian intestine harbors a beneficial microbiota numbering approximately 1012 organisms per gram of colonic content. The host tolerates this tremendous bacterial load while maintaining theExpand
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Polysaccharide Biosynthesis Locus Required for Virulence of Bacteroides fragilis
ABSTRACT Bacteroides fragilis, though only a minor component of the human intestinal commensal flora, is the anaerobe most frequently isolated from intra-abdominal abscesses. B. fragilis 9343Expand
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Phylum‐wide general protein O‐glycosylation system of the Bacteroidetes
The human gut symbiont Bacteroides fragilis has a general protein O‐glycosylation system in which numerous extracytoplasmic proteins are glycosylated at a three amino acid motif. In B. fragilis,Expand
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