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Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
TLDR
Genes affected by de novo CNVs and/or loss-of-function single-nucleotide variants converged on networks related to neuronal signaling and development, synapse function, and chromatin regulation and were overrepresented among subjects with fragile X syndrome protein targets. Expand
Phytoestrogen Content of Foods Consumed in Canada, Including Isoflavones, Lignans, and Coumestan
TLDR
A database of nine phytoestrogens in foods relevant to Western diets was developed to more accurately estimate intakes and the richest sources of specific phy toestrogens, including coumestrol, were identified. Expand
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
TLDR
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer. Expand
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
TLDR
An association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 is identified, consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreaticcancer than those with groups A or B. Expand
Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian women
TLDR
The validity and reliability of the most recent adaptation of Block's full-diet food-frequency questionnaire (FFQ) were moderate to high, supporting its use in future studies among Canadian women. Expand
Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.
TLDR
The increased risk of colorectal cancer in biallelic and monoallelic MYH gene mutation carriers was not consistently associated with the development of multiple adenomatous polyps and may account for a substantial fraction of hereditary coloreCTal cancer. Expand
Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup.
TLDR
Heterogeneity exists in the risk factor profiles of ER+PR+ and ER-PR- premenopausal breast cancer; however, risk factors did not differ markedly for postmenopausal Breast cancer. Expand
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
TLDR
This study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies and identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.1 that are associated with multiple cancers. Expand
Vitamin D-Related Genetic Variants, Interactions with Vitamin D Exposure, and Breast Cancer Risk among Caucasian Women in Ontario
TLDR
Limited evidence is found that genetic variants modify the associations between vitamin D exposure and breast cancer risk and certain vitamin D related genetic variants may influence breast-cancer risk. Expand
Detectable clonal mosaicism and its relationship to aging and cancer
TLDR
Large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. Expand
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