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The discovery of potent cRaf1 kinase inhibitors.
Design, synthesis, and DNA binding properties of bifunctional intercalators. Comparison of polymethylene and diphenyl ether chains connecting phenanthridine
Binding and kinetics studies of oxidation of DNA by oxoruthenium(IV)
The binding to DNA of complexes based on Ru(tpy)(L)OH 2 2+ (tpy=2,2',2''-terpyridine; L=bpy, 2,2'-bipyridine; phen, 1,10-phenanthroline; or dppz, dipyridophenazine) has been studied by viscometry,…
Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
HCPA1 and hCPA2 are potential candidates for use in a human-based ADEPT approach and kinetic data show that hCpa2 has a larger substrate binding site than the hC PA1 enzyme.
Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles).
Molecular modeling studies and the biophysical data suggest that the molecules bind to the minor groove of CT DNA and homopolymers and analysis of the shape of the molecules is consistent with this mode of nucleic acid binding.
Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity
- C. Bell, M. Cory, T. Fairley, J. Hall, R. Tidwell
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 June 1991
A mode of antigiardial activity for these compounds was suggested by the correlation observed between antigiARDial activity and the binding of the compounds to calf thymus DNA and poly(dA).poly(dT).
Molecular Diversity in Chemical Databases: Comparison of Medicinal Chemistry Knowledge Bases and Databases of Commercially Available Compounds
- D. Cummins, C. W. Andrews, J. Bentley, M. Cory
- Chemistry, Computer ScienceJ. Chem. Inf. Comput. Sci.
- 1 July 1996
An analysis of overlap between the biological and commercial databases was carried out and the metric provides a useful algorithm for choosing screening sets of diverse compounds from large databases.
Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase.
Covalent Binding of Aquaruthenium Complexes to DNA
2-[(arylmethyl) amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding.
- K. Bair, C. W. Andrews, R. Tuttle, V. Knick, M. Cory, D. D. Mckee
- Chemistry, BiologyJournal of medicinal chemistry
- 1 July 1991
The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols were examined and appears to be related to the shape of the specific molecule.