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- Influence
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl
- M. Cortese-Krott, Gunter G. C. Kuhnle, +15 authors M. Feelisch
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 29 July 2015
Significance Reactions of sulfur-centered nucleophiles with nitrogenous species have been studied independently for more than a century for synthetic/industrial purposes; to understand geochemical,… Expand
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
- M. Cortese-Krott, A. Rodriguez-Mateos, +11 authors M. Kelm
- Biology, Medicine
- Blood
- 15 November 2012
A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain. Using… Expand
Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆
- M. Cortese-Krott, Bernadette O. Fernandez, +6 authors M. Feelisch
- Chemistry, Medicine
- Redox biology
- 11 January 2014
Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is… Expand
Circulating Microparticles Carry a Functional Endothelial Nitric Oxide Synthase That Is Decreased in Patients With Endothelial Dysfunction
- P. Horn, M. Cortese-Krott, +4 authors C. Heiss
- Medicine
- Journal of the American Heart Association
- 31 December 2012
Background Microparticles (MPs) are circulating membrane particles of less than a micrometer in diameter shed from endothelial and blood cells. Recent literature suggests that MPs are not just… Expand
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine
- M. Cortese-Krott, A. Koning, +9 authors M. Feelisch
- Biology, Medicine
- Antioxidants & redox signaling
- 1 October 2017
Abstract Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of antioxidants is… Expand
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
- V. Kuhn, L. Diederich, +7 authors M. Cortese-Krott
- Biology, Medicine
- Antioxidants & redox signaling
- 1 May 2017
Abstract Significance: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events, stroke,… Expand
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial
- C. Heiss, R. Sansone, +10 authors M. Kelm
- Medicine
- AGE
- 27 May 2015
Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake can improve vascular function in healthy… Expand
Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function.
- R. Erkens, Christian M. Kramer, +9 authors M. Cortese-Krott
- Medicine
- Free radical biology & medicine
- 1 December 2015
Increased production of reactive oxygen species and failure of the antioxidant defense system are considered to play a central role in the pathogenesis of cardiovascular disease. The transcription… Expand
Nitric Oxide Synthase Expression and Functional Response to Nitric Oxide Are Both Important Modulators of Circulating Angiogenic Cell Response to Angiogenic Stimuli
- C. Heiss, A. Schanz, +9 authors M. Springer
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 November 2010
Objective—Circulating angiogenic cells (CACs), also termed endothelial progenitor cells, play an integral role in vascular repair and are functionally impaired in coronary artery disease (CAD). The… Expand
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.
- Alexander S. Keller, L. Diederich, +8 authors B. Isakson
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 December 2017
Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to… Expand