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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
TLDR
The role of noncanonical functions of RBCs in the cardiovascular system and their dysfunction in anemia are revised and discussed both in animal models and clinical settings.
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl
TLDR
The results unveil an unexpectedly rich network of coupled chemical reactions between NO and H2S/sulfide, suggesting that the bioactivity of either transmitter is governed by concomitant formation of polysulfides and anionic S/N-hybrid species.
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
TLDR
It is demonstrated that human RBCs contain an endothelial NOS (eNOS) that converts L-(3)H-arginine to L-citrulline in a Ca(2+)/calmodulin-dependent fashion and in patients with coronary artery disease, red cell eNOS expression and activity are lower than in age-matched healthy individuals and correlate with the degree of endothelial dysfunction.
Nitric Oxide Synthase Expression and Functional Response to Nitric Oxide Are Both Important Modulators of Circulating Angiogenic Cell Response to Angiogenic Stimuli
TLDR
In CAD patients, impairment of NOS expression and NO bioavailability, rather than response to NO, may contribute to dysfunction of CACs and limit their regenerative capacity.
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial
TLDR
CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health.
Circulating Microparticles Carry a Functional Endothelial Nitric Oxide Synthase That Is Decreased in Patients With Endothelial Dysfunction
TLDR
The concept that circulating MPs may not only retain phenotypic markers but also preserve the functionality of enzymes of the cells they originate from is supported, including eNOS.
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.
TLDR
The data presented here question the importance of Panx1 for exercise performance and dispute the general assumption that ATP release from RBCs via PanX1 is regulated via cAMP.
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine
TLDR
This work introduces a novel integrative concept defined as the reactive species interactome (RSI), a primeval multilevel redox regulatory system whose architecture allows efficient sensing and rapid adaptation to environmental changes and various other stressors to enhance fitness and resilience at the local and whole-organism level.
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