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HIF-1alpha is essential for myeloid cell-mediated inflammation.
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts ofExpand
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts ofExpand
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia.
B cell chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature, functionally incompetent B cells. Wnts are a large family of secreted glycoproteins involved in cellExpand
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
Vaccination with naked DNA elicits cellular and humoral immune responses that have a T helper cell type 1 bias. However, plasmid vectors expressing large amounts of gene product do not necessarilyExpand
IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis.
During atherogenesis, LDL is oxidized, generating various oxidation-specific neoepitopes, such as malondialdehyde-modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup ofExpand
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.
Osteoarthritis (OA) is a leading cause of disability in Western society with multiple risk factors, including a complex genetic pattern. Identifying loci involved in the heredity of OA might lead toExpand
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of oxidized lipoproteins and apoptotic cells. Adaptive immune responses to various oxidation-specific epitopes playExpand
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressedExpand
A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells1
Dendritic cells (DCs) are capable of cross-presenting exogenous Ag to CD8+ CTLs. Detection of microbial products by Toll-like receptors (TLRs) leads to activation of DCs and subsequent orchestrationExpand
Classification of osteoarthritis biomarkers: a proposed approach.
OBJECTIVE Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effectiveExpand
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