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mTOR in aging, metabolism, and cancer.
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TORExpand
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Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
Significance The mammalian target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to nutrients, growth factors, and cellular energy. Aberrant mTORC1 signaling isExpand
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Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia
BACKGROUND Overnight memory consolidation is disturbed in both depression and schizophrenia, creating an ideal situation to investigate the mechanisms underlying sleep-related consolidation and toExpand
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mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.
Orexigenic agouti-related protein/neuropeptide Y (Agrp/NPY) neurons and an orexigenic pro-opiomelanocortin (POMC) neurons of the hypothalamus regulate feeding behavior and energy homeostasis. AnExpand
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Targeted pharmacological therapy restores β-cell function for diabetes remission
Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be targeted byExpand
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mTORC1 and mTORC2 in energy homeostasis
Publisher Summary This chapter discusses the role of mammalian target of rapamycin complex 1 (mTORC1) and mammalian target of rapamycin complex 2 (mTORC2) in energy homeostasis. Energy homeostasis isExpand
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Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission
An amendment to this paper has been published and can be accessed via a link at the top of the paper.