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Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration.
Apoptotic nerve cell death is implicated in the pathogenesis of several devastating neurodegenerative conditions, including glaucoma and Alzheimer's and Parkinson's diseases. We have devised aExpand
Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery.
PURPOSE Postoperative subconjunctival wound healing remains the commonest cause of late bleb failure after glaucoma filtration surgery. This study was undertaken to investigate whether the humanExpand
Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent.
PURPOSE Currently available anti-scarring regimens for glaucoma filtration surgery have potentially blinding complications and thus the need for alternative and safer agents. The effects of a newExpand
Cystic bleb formation and related complications in limbus- versus fornix-based conjunctival flaps in pediatric and young adult trabeculectomy with mitomycin C.
OBJECTIVE Comparison of fornix- and limbus-based conjunctival flaps with respect to cystic bleb-related complications of trabeculectomy with high-dose mitomycin C (MMC) in pediatric and young adultExpand
Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome
The scarring response is an important factor in many diseases throughout the body. In addition, it is a major problem in influencing results of surgery. In the eye, for example, post-operativeExpand
Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit.
PURPOSE To investigate the effect of varying the treatment area of subconjunctival mitomycin-C (MMC) using an adapted rabbit model of filtration surgery. METHODS Twenty-four New Zealand WhiteExpand
Accuracy of intraocular pressure measurements in new zealand white rabbits.
PURPOSE Rabbits are commonly used for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The accuracy of intraocular pressure measurement is therefore critical in the analysisExpand
The role of the immune system in conjunctival wound healing after glaucoma surgery.
The immune system has a fundamental role in the development and regulation of ocular healing, which plays an important role in the pathogenesis of most blinding diseases. This review discusses theExpand
TGF-β1, -β2, and -β3 In Vitro: Biphasic Effects on Tenon’s Fibroblast Contraction, Proliferation, and Migration
Purpose, To compare the effects of the three human transforming growth factor-beta (TGF-beta) isoforms and different concentrations of TGF-beta on human Tenon's capsule fibroblasts (HTF), with a viewExpand
Modulating conjunctival wound healing
Advances in molecular and cell biology have led to an expansion in our knowledge and understanding of the processes involved in wound healing. We review existing and potential therapies modulatingExpand