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Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration.
TLDR
A noninvasive real-time imaging technique using confocal laser-scanning ophthalmoscopy to visualize single nerve cell apoptosis in vivo, which allows longitudinal study of disease processes that has not previously been possible.
Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit.
PURPOSE To investigate the effect of varying the treatment area of subconjunctival mitomycin-C (MMC) using an adapted rabbit model of filtration surgery. METHODS Twenty-four New Zealand White
Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery.
TLDR
Postoperative administration of CAT-152 significantly improved surgical outcome, reduced subconjunctival scarring, and minimized the risk of corneal side effects compared with the anti-scarring agent 5-FU.
Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent.
TLDR
Subconjunctival rhAnti-TGF-beta2 mAb treatment significantly affects surgical outcome and effectively reduces conjunctival scarring both in vitro and in vivo, and may have potential as a new anti-scarring agent for use in glaucoma filtration surgery.
Modulation of wound healing after glaucoma surgery
TLDR
The authors review the changes in how to use antimetabolites to improve safety, and many of the exciting new areas of progress, including growth factor neutralization and future molecular therapies to control wound healing.
Accuracy of intraocular pressure measurements in new zealand white rabbits.
TLDR
The Perkins applanation tonometer was the most reliable for measuring IOP in the range of 0 to 50 mm Hg in New Zealand White rabbits, with increasing inaccuracy at higher pressures.
Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome
TLDR
The findings suggest that TGF-β antisense oligonucleotides have potential as a new therapy for reducing post-surgical scarring and its long-lasting effects after only a single administration at the time of surgery make it particularly attractive clinically.
Modulating conjunctival wound healing
TLDR
Use of fully human neutralising monoclonal antibodies to the growth factor TGFfβ has potential as a useful strategy for modifying conjunctival scarring.
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