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Optical biosensors in drug discovery
- M. Cooper
- Computer Science, Medicine
- Nature Reviews Drug Discovery
- 1 July 2002
Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors have been used widely over the past decade to analyse biomolecular interactions. Expand
Human Monocytes Engage an Alternative Inflammasome Pathway.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of… Expand
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Faulty blood cells and heart disease Recent studies have shown that elderly people's blood cells often harbor mutations in genes encoding certain epigenetic regulators. These mutations can lead to… Expand
Biomarkers in chronic kidney disease: a review.
- R. Fassett, S. Venuthurupalli, G. Gobe, J. Coombes, M. Cooper, W. Hoy
- Kidney international
- 2 October 2011
Chronic kidney disease (CKD) is a major public health problem. The classification of CKD by KDOQI and KDIGO and the routine eGFR reporting have resulted in increased identification of CKD. It is… Expand
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox
The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence against a range of infectious agents, and is driven by the assembly of a multi-protein complex containing a… Expand
Emerging pathogenic links between microbiota and the gut–lung axis
The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently… Expand
Imperfect coordination chemistry facilitates metal ion release in the Psa permease.
The relative stability of divalent first-row transition metal ion complexes, as defined by the Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal ion… Expand
Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals
BackgroundOur view of host-associated microbiota remains incomplete due to the presence of as yet uncultured constituents. The Bacteroidales family S24-7 is a prominent example of one of these… Expand
A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions
The widespread exploitation of biosensors in the analysis of molecular recognition has its origins in the mid‐1990s following the release of commercial systems based on surface plasmon resonance… Expand
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells
Innate immune crosstalk in T cells The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive… Expand