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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
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Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
BACKGROUND In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain. METHODS We randomly assigned 11,140 patients with type 2 diabetes toExpand
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Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Glucose metabolism is normally regulated by a feedback loop including islet β cells and insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell response. IfExpand
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Mechanisms of diabetic complications.
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. TheseExpand
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Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.
BACKGROUND Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin-angiotensin system slows the progression of renal disease in patients with type 1 diabetes,Expand
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A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.
BACKGROUND Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa can effectivelyExpand
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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains <25% of the variation inExpand
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Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril
Abstract Objectives: To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and typeExpand
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Clinical review: The role of advanced glycation end products in progression and complications of diabetes.
  • S. Goh, M. Cooper
  • Medicine
  • The Journal of clinical endocrinology and…
  • 1 April 2008
CONTEXT Diabetic complications appear to be multifactorial in origin, but in particular, the biochemical process of advanced glycation, which is accelerated in diabetes as a result of chronicExpand
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