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Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes.
- J. Rejman, A. Bragonzi, M. Conese
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 1 September 2005
We investigated the effects of inhibitors of clathrin-mediated endocytosis (chlorpromazine and K(+) depletion) and of caveolae-mediated uptake (filipin and genistein) on internalization of… Expand
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)- dependent internalization of the urokinase receptor
- M. Conese, A. Nykjaer, +6 authors F. Blasi
- Biology, Medicine
- The Journal of cell biology
- 2 December 1995
The GPI-anchored urokinase plasminogen activator receptor (uPAR) does not internalize free urokinase (uPA). On the contrary, uPAR-bound complexes of uPA with its serpin inhibitors PAI-1 (plasminogen… Expand
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
The GPI‐anchored urokinase plasminogen activator receptor (uPAR) does not internalize free urokinase (uPA) but readily internalizes and degrades uPA:serpin complexes in a process that requires the… Expand
Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma.
- L. Galietta, C. Folli, +4 authors O. Zegarra-Moran
- Medicine, Chemistry
- American journal of physiology. Lung cellular and…
- 1 June 2000
Human bronchial epithelial cells were treated in vitro with interferon-gamma or tumor necrosis factor-alpha to assess their effect on transepithelial ion transport. Short-circuit current measurements… Expand
Cytokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy.
It is not known whether cytokine levels in sputum may be used as outcome measures after parenteral antibiotic therapy in cystic fibrosis (CF) patients. Here, we assessed the effects of antibiotic… Expand
Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs
Biodistribution of nonviral cationic vector/DNA complexes was studied after systemic or intratracheal administration to the lungs and correlated with transgene expression. Intravenous injection in… Expand
Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosis.
The high prevalence of hypermutable (mismatch repair-deficient) Pseudomonas aeruginosa strains in patients with cystic fibrosis (CF) is thought to be driven by their co-selection with adaptive… Expand
Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells.
- S. Carrabino, D. Carpani, +5 authors M. Conese
- Journal of cystic fibrosis : official journal of…
- 1 May 2006
BACKGROUND It is not clear whether cystic fibrosis (CF) airway inflammation is a consequence of bacterial infection or is intrinsically dysregulated. The aim of this study was to investigate IL-8… Expand
Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.
- A. Bragonzi, D. Worlitzsch, +7 authors G. Doring
- Medicine, Biology
- The Journal of infectious diseases
- 1 August 2005
BACKGROUND In patients with cystic fibrosis (CF), lung infection with mucoid Pseudomonas aeruginosa strains overexpressing the exopolysaccaride alginate is preceded by colonization with nonmucoid… Expand
Na+/H+ Exchanger Regulatory Factor 1 Overexpression-dependent Increase of Cytoskeleton Organization Is Fundamental in the Rescue of F508del Cystic Fibrosis Transmembrane Conductance Regulator in…
- M. Favia, L. Guerra, +9 authors V. Casavola
- Biology, Medicine
- Molecular biology of the cell
- 1 January 2010
NHERF1 overexpression increases functional apical expression of F508del CFTR in CFBE41o- cells. Here, we show that this occurs via the formation of the multiprotein complex NHERF1-phosphoezrin-actin,… Expand