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TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation
It is shown that ILC2s are always present in healthy skin, but accumulate in AD lesions and function by a mechanism that contrasts what has been reported in lungs and intestine, suggesting that targeting group 2 ILCs will be a viable target for treating AD and other allergic diseases.
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.
- M. Smithgall, M. Comeau, B. P. Yoon, D. Kaufman, R. Armitage, Dirk E. Smith
- BiologyInternational immunology
- 1 August 2008
Results indicate that in addition to its activity on human mast cells, IL-33 is capable of activating human basophils, polarized T cells, iNKT and NK cells, and the nature of the responses elicited by IL- 33 suggests that this axis may amplify both T(h)1- and T( h)2-oriented immune responses.
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
It is shown that TslP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor–deficient mice had considerably attenuated disease.
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
- Z. Allakhverdi, M. Comeau, G. Delespesse
- Biology, MedicineThe Journal of experimental medicine
- 19 February 2007
It is shown that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs) and is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.
A complementary DNA was isolated that encodes the high-affinity converting subunit of the LIF receptor, identical to the signal transducing sub unit of the IL-6 receptor, gp130, which confers high- Affinity binding of both LIF and OSM when expressed with the low-Affinity Lif receptor.
Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities
It is demonstrated for the first time that IL-25-mediated activities require both IL-17RB andIL-17RA and provide another example of an IL- 17 family ligand that utilizes a heteromeric receptor complex.
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
Transgenic mice generate transgenic mice that demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
It is shown that TSLP–TSLPR interactions are critical for immunity to the intestinal pathogen Trichuris, and neutralization of IFN-γ in Trichuis-infected TSLPR−/− mice restored Th2 cytokine responses and resulted in worm expulsion, providing the first demonstration of T SLPR-independent pathways for Th2ocyte production.
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappa B activity and interleukin-6 secretion in fibroblasts, and costimulate T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb, respectively.