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A comparison of 11β-chloromethlylestradiol and tamoxifen aziridine as affinity labeling reagents for estrogen receptors
The tritium-labeled from of 11 beta-chloromethylestradiol was prepared by metal hydride reduction of the 17-keto derivative. Affinity labeling experiments were carried out using [3H] 11Expand
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2-Chloro-1-methoxymethylindole-3-carboxaldehyde: Introduction of Nucleophiles into the Indole 2-Position and an Approach to the Unusual TrpHis Fragment of Moroidin
2-Chloro-1-methoxymethylindole-3-carboxaldehyde (3) is an excellent substrate for a range of nitrogen nucleophiles and gives 2-substituted indoles. Use of a histidine based nucleophile results in theExpand
  • 31
Depsidone synthesis. Part 24. The synthesis of epiphorellic acid 2. A pseudodepsidone and X-ray crystal structure of a grisadienedione epoxide
The synthesis of the unusual pseudo-depsidone epiphorellic acid 2 (2){6-hydroxy-3-[5-hydroxy-2-methoxycarbonyl-3-(3-oxopentylphenoxy]-4-methoxy-2-pentylbenzoic acid} by a route involvingExpand
  • 13
Synthesis of Some 1,2,3,8-Tetrasubstituted Naphthalenes
Effcient methods for the synthesis of 3,4,5-trimethoxynaphthalene-2-carboxylic acid (7) and 2,8-dimethoxy-3-methylnaphthalene-1-carboxylic acid (25) are described.
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Synthesis of larreantin, a cytotoxic naphthoquinonoid sesquilignan from Larrea tridentata
Larreantin [8-(4-hydroxy-3-methoxyphenyl)-6-(4-hydroxy-3-methoxybenzyl)-2-methoxy-7-methyl-naphthalene-1,4-dione]1, a biogenetically unique cytotoxic naphthoquinonoid sesquilignan has beenExpand
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The synthesis of pacharin: a dibenzoxepine from the heartwood of Bauhinia racemosa Lamk.
The synthesis of the novel dibenzoxepine derivative pacharin (13)(8-methoxy-7-methyldibenz[b,f]-oxepine-1,6-diol), a constituent of the heartwood of Bauhinia racemosa Lamk., is described The routeExpand
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Synthesis of larreantin, a novel, cytotoxic naphthoquinone from Larrea tridentata
Larreantin, a biogenetically unique cytotoxic naphthoquinone, has been synthesized by a convergent route which depends upon the selective functionalization of a naphthyldihydro-oxazole.
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