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- Publications
- Influence
A comparison of 11β-chloromethlylestradiol and tamoxifen aziridine as affinity labeling reagents for estrogen receptors
- T. Ratajczak, V. Atrache, P. Antes, M. Comber, R. Hähnel
- Chemistry, Medicine
- Steroids
- 1 May 1988
The tritium-labeled from of 11 beta-chloromethylestradiol was prepared by metal hydride reduction of the 17-keto derivative. Affinity labeling experiments were carried out using [3H] 11… Expand
2-Chloro-1-methoxymethylindole-3-carboxaldehyde: Introduction of Nucleophiles into the Indole 2-Position and an Approach to the Unusual TrpHis Fragment of Moroidin
2-Chloro-1-methoxymethylindole-3-carboxaldehyde (3) is an excellent substrate for a range of nitrogen nucleophiles and gives 2-substituted indoles. Use of a histidine based nucleophile results in the… Expand
Depsidone synthesis. Part 24. The synthesis of epiphorellic acid 2. A pseudodepsidone and X-ray crystal structure of a grisadienedione epoxide
- M. Comber, M. V. Sargent, B. W. Skelton, A. H. White
- Chemistry
- 1989
The synthesis of the unusual pseudo-depsidone epiphorellic acid 2 (2){6-hydroxy-3-[5-hydroxy-2-methoxycarbonyl-3-(3-oxopentylphenoxy]-4-methoxy-2-pentylbenzoic acid} by a route involving… Expand
Synthesis of Some 1,2,3,8-Tetrasubstituted Naphthalenes
- M. Comber, J. Morris, M. V. Sargent
- Chemistry
- 1998
Effcient methods for the synthesis of 3,4,5-trimethoxynaphthalene-2-carboxylic acid (7) and 2,8-dimethoxy-3-methylnaphthalene-1-carboxylic acid (25) are described.
Synthesis of larreantin, a cytotoxic naphthoquinonoid sesquilignan from Larrea tridentata
- M. Comber, M. V. Sargent
- Chemistry
- 1991
Larreantin [8-(4-hydroxy-3-methoxyphenyl)-6-(4-hydroxy-3-methoxybenzyl)-2-methoxy-7-methyl-naphthalene-1,4-dione]1, a biogenetically unique cytotoxic naphthoquinonoid sesquilignan has been… Expand
The synthesis of pacharin: a dibenzoxepine from the heartwood of Bauhinia racemosa Lamk.
- M. Comber, M. V. Sargent
- Chemistry
- 1990
The synthesis of the novel dibenzoxepine derivative pacharin (13)(8-methoxy-7-methyldibenz[b,f]-oxepine-1,6-diol), a constituent of the heartwood of Bauhinia racemosa Lamk., is described The route… Expand
Synthesis of Some 1,2,3,8-Tetrasubstituted Naphthalenes.
- M. Comber, J. Morris, M. V. Sargent
- Chemistry
- 7 July 1998
Depsidone Synthesis. Part 24. The Synthesis of Epiphorellic Acid 2. A Pseudo-Depsidone and X-Ray Crystal Structure of a Grisadienedione Epoxide.
- M. Comber, M. V. Sargent, B. W. Skelton, A. White
- Chemistry
- 20 June 1989
Synthesis of larreantin, a novel, cytotoxic naphthoquinone from Larrea tridentata
- M. Comber, M. V. Sargent
- Chemistry
- 1991
Larreantin, a biogenetically unique cytotoxic naphthoquinone, has been synthesized by a convergent route which depends upon the selective functionalization of a naphthyldihydro-oxazole.