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Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy
Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy is likely to be a class side effect of these drugs, although its severity is largely variable,Expand
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Small-angle neutron scattering reveals the assembly mode and oligomeric architecture of TET, a large, dodecameric aminopeptidase
The present work illustrates that small-angle neutron scattering, deuteration and contrast variation, combined with in vitro particle reconstruction, constitutes a very efficient approach toExpand
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Practical stereoselective synthesis of conformationally constrained unnatural proline-based amino acids and peptidomimetics
Abstract A practical synthetic scheme was developed to prepare both the cis- and trans-fused stereoisomers of N-Boc- l -octahydroindole-2-carboxylic acid ( l -Oic) methyl ester. Key event of theExpand
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Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo.
We analysed the action, in rats in vivo, of the protein isoprenylation inhibitor perillyl alcohol (POH) and that of vitamin A, alone or in association, on m-RNA and protein expression ofExpand
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Phosphorus trichloride-mediated and microwave-assisted synthesis of a small collection of amides bearing strong electron-withdrawing group substituted anilines.
The amide bond is a fundamental linkage tool in organic synthesis and, especially, in medicinal chemistry, because of its metabolic stability and its propensity for establishing intermolecularExpand
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Synthesis of spiroazabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics
Abstract A practical approach to the synthesis of a conformationally constrained spiroazabicycloalkane aminoacid scaffold as a reverse-turn inducer dipeptide mimic is described.
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Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites
TET aminopeptidases are dodecameric particles shared in the three life domains involved in various biological processes, from carbon source provider in archaea to eye-pressure regulation in humans.Expand
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Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols
O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst.Expand
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