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Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy
Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy is likely to be a class side effect of these drugs, although its severity is largely variable,… Expand
Endoscopy Units and the Coronavirus Disease 2019 Outbreak: A Multicenter Experience From Italy
Small-angle neutron scattering reveals the assembly mode and oligomeric architecture of TET, a large, dodecameric aminopeptidase
- Alexandre Appolaire, E. Girard, +5 authors F. Gabel
- Medicine, Chemistry
- Acta crystallographica. Section D, Biological…
- 23 October 2014
The present work illustrates that small-angle neutron scattering, deuteration and contrast variation, combined with in vitro particle reconstruction, constitutes a very efficient approach to… Expand
Practical stereoselective synthesis of conformationally constrained unnatural proline-based amino acids and peptidomimetics
Abstract A practical synthetic scheme was developed to prepare both the cis- and trans-fused stereoisomers of N-Boc- l -octahydroindole-2-carboxylic acid ( l -Oic) methyl ester. Key event of the… Expand
Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo.
We analysed the action, in rats in vivo, of the protein isoprenylation inhibitor perillyl alcohol (POH) and that of vitamin A, alone or in association, on m-RNA and protein expression of… Expand
Phosphorus trichloride-mediated and microwave-assisted synthesis of a small collection of amides bearing strong electron-withdrawing group substituted anilines.
- M. Colombo, Stefano Bossolo, A. Aramini
- Medicine, Chemistry
- Journal of combinatorial chemistry
- 27 March 2009
The amide bond is a fundamental linkage tool in organic synthesis and, especially, in medicinal chemistry, because of its metabolic stability and its propensity for establishing intermolecular… Expand
Synthesis of spiroazabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics
Abstract A practical approach to the synthesis of a conformationally constrained spiroazabicycloalkane aminoacid scaffold as a reverse-turn inducer dipeptide mimic is described.
Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites
TET aminopeptidases are dodecameric particles shared in the three life domains involved in various biological processes, from carbon source provider in archaea to eye-pressure regulation in humans.… Expand
Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols
O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst.… Expand
Practical Stereoselective Synthesis of Conformationally Constrained Unnatural Proline-Based Amino Acids and Peptidomimetics.