Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion.
- M. Collino, M. Aragno, R. Fantozzi
- BiologyEuropean Journal of Pharmacology
- 13 January 2006
Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction
- P. Tripatara, N. Patel, C. Thiemermann
- BiologyLaboratory Investigation
- 4 August 2008
The findings suggest that the synthesis of endogenous hydrogen sulfide by CSE is essential to protect the kidney against ischemia/reperfusion injury and dysfunction and aids in the recovery of renal function following ischemIA/rePerfusion.
ANTI-APOPTOTIC AND ANTI-INFLAMMATORY EFFECTS OF HYDROGEN SULFIDE IN A RAT MODEL OF REGIONAL MYOCARDIAL I/R
- A. Sivarajah, M. Collino, C. Thiemermann
- BiologyShock
- 1 March 2009
It is demonstrated that the cardioprotective effect of NaHS is secondary to a combination of antiapoptotic and anti-inflammatory effects.
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
- M. Collino, M. Aragno, R. Fantozzi
- Medicine, BiologyBritish Journal of Pharmacology
- 1 August 2010
This study investigated the hepatic signalling pathway activated by PPARγ activation in a non‐genetic insulin‐resistant animal model to investigate the involvement of suppressor of cytokine signalling (SOCS‐3) in the pathogenesis of insulin resistance.
Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-α agonist WY14643
- M. Collino, M. Aragno, R. Fantozzi
- Biology
- 15 August 2006
PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss
- G. Miglio, A. C. Rosa, L. Rattazzi, M. Collino, G. Lombardi, R. Fantozzi
- BiologyNeurochemistry International
- 1 December 2009
Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
- M. Collino, M. Rogazzo, E. Masini
- Biology, MedicineJournal of Cellular and Molecular Medicine
- 20 September 2013
It is reported herein that rhRLX protects the kidney against I/R injury by a mechanism that involves changes in nitric oxide signalling pathway.
Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes
- G. Purvis, F. Chiazza, E. Solito
- Medicine, BiologyDiabetologia
- 30 October 2017
It is demonstrated that ANXA1 plasma levels are elevated in individuals with type 1 diabetes independent of a significant impairment in renal function, and in mouse models with STZ-induced type 2 diabetes, ANxA1 protects against cardiac and renal dysfunction by returning MAPK signalling to baseline and activating pro-survival pathways.
Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways
- R. Mastrocola, C. Penna, M. Collino
- Biology, MedicineOxidative Medicine and Cellular Longevity
- 8 December 2016
It is demonstrated for the first time that INF4E protected against the IR-induced myocardial injury and dysfunction, by a mechanism that involves inhibition of the NLRP3 inflammasome, resulting in the activation of the prosurvival RISK pathway and improvement in mitochondrial function.
Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases
- Vanesa Cepas, M. Collino, J. Mayo, R. Sainz
- BiologyAntioxidants
- 1 February 2020
All evidence that relates AGEs and ROS production, their relationship with diet-related diseases, as well as the latest research about the use of natural compounds with antioxidant properties to prevent the harmful effects of A GEs on health are summarized.
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