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Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
AKAPs: from structure to function.
Regulation of GluR1 by the A-Kinase Anchoring Protein 79 (AKAP79) Signaling Complex Shares Properties with Long-Term Depression
- S. J. Tavalin, M. Colledge, J. Hell, L. Langeberg, R. Huganir, John D. Scott
- BiologyThe Journal of Neuroscience
- 15 April 2002
It is demonstrated that AKAP79 not only promotes basal phosphorylation of Ser845 but also confers a calcium- and PP2B-mediated downregulation to GluR1 receptor currents, suggesting that the integration of intracellular signals relevant for LTD may be transduced to GLUR1 by theAKAP79 signaling complex.
Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression*
- E. Snyder, M. Colledge, R. Crozier, Wendy S. Chen, John D. Scott, M. Bear
- BiologyJournal of Biological Chemistry
- 29 April 2005
It is shown that a threshold level of NMDA receptor activation must be exceeded to trigger a stable loss of AMPA receptors from the surface of cultured hippocampal neurons, and it is demonstrated in hippocampal slices that displacement of PKA from AKADs occludes synaptically induced long term depression.
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor β subunits
Signals mediating ion channel clustering at the neuromuscular junction
Tyrosine Phosphorylation of Nicotinic Acetylcholine Receptor Mediates Grb2 Binding
A novel role for tyrosine phosphorylation of the AChR is suggested in the initiation of a Grb2-mediated signaling cascade at the postsynaptic membrane and a cytoplasmic domain of the δ subunit contains a binding motif for the SH2 domain of Grb 2.
To muster a cluster: anchoring neurotransmitter receptors at synapses.
This commentary will focus on the synaptic clustering and anchoring of neurotransmitter receptors through their association with a variety of cytoplasmic proteins.
Clustering of the acetylcholine receptor by the 43-kD protein: involvement of the zinc finger domain
- P. Scotland, M. Colledge, I. Melnikova, Z. Dai, S. Froehner
- BiologyThe Journal of cell biology
- 1 November 1993
The findings suggest that protein interactions via the zinc finger domain of the 43- kD protein may be important for AChR clustering at the synapse.