Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.
- M. Coleman, J. Donofrio, J. Dyminski
- Biology, MedicineJournal of Biological Chemistry
- 10 March 1978
Observation of abnormal deoxynucleotide metabolism suggests interference with DNA synthesis as a new explanation of the normal nucleotide pool disruption in an untreated child with adenosine deaminase deficiency and severe combined immunodeficiency disease.
Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase.
- B. Yang, K. Gathy, M. Coleman
- BiologyJournal of Biological Chemistry
- 22 April 1994
Results indicated that the aspartic acid residue at position 343 is located at or near the active site and is critical for the nucleotide binding and catalytic activity in human terminal deoxynucleotidyl transferase.
ATP depletion as a consequence of adenosine deaminase inhibition in man.
- M. Siaw, B. Mitchell, C. Koller, M. Coleman, J. Hutton
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 October 1980
The rapid and unexpected depletion of ATP associated with dATP accumulation may account, at least in part, for the toxicity associated with 2'-deoxycoformycin administration, which raises major questions about the control of energy metabolism in erythrocytes.
Serial observations on terminal deoxynucleotidyl transferase activity and lymphoblast surface markers in acute lymphoblastic leukemia.
- M. Coleman, M. Greenwood, J. Hutton, F. Bollum, B. Lampkin, P. Holland
- Medicine, BiologyCancer Research
- 1976
Terminal deoxynucleotidyl transferase activity and cell surface markers were measured in peripheral lymphoid cells from 27 children with acute lymphoblastic leukemia in various phases of their disease and may be important in the evaluation of therapeutic effectiveness in acute lymphoblast leukemia.
Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
- J. Meier, M. Coleman, J. Hutton
- Medicine, BiologyBritish Journal of Cancer
- 1 March 1976
Adenosine deaminase (EC 3.5.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies but the ranges of activities per cell were so similar that ADA assay is unlikely to be of major help in distinguishing the two diseases.
Terminal deoxynucleotidyltransferase distribution in neoplastic and hematopoietic cells.
- M. Greenwood, M. Coleman, P. Holland
- Medicine, BiologyJournal of Clinical Investigation
- 1 May 1977
Marrow terminal deoxynucleotidyltrnasferase values obtained during the active phase of acute lymphoblastic leukemia were significantly greater than those found in other types of leukemia, bone marrow malignancies, and hematologic disorders.
Terminal deoxynucleotidyl transferase: characterization of extraction and assay conditions from human and calf tissue.
- M. Coleman
- BiologyArchives of Biochemistry and Biophysics
- 1 August 1977
Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.
- J. Donofrio, M. Coleman, J. Hutton, A. Daoud, B. Lampkin, J. Dyminski
- Medicine, BiologyJournal of Clinical Investigation
- 1 October 1978
Elevated dATP levels in lymphocytes and bone marrow, and increased urinary excretion of deoxyadenosine, persisted despite hypertransfusion of the child with irradiated erythrocytes from a donor with normal adenosine deaminase.
Terminal Deoxynucleotidyl Transferase Measurements in the Differential Diagnosis of Adult Leukaemias
- J. Hutton, M. Coleman
- Medicine, BiologyBritish Journal of Haematology
- 1 November 1976
Terminal deoxynucleotidyl transferase is an unusual DNA polymerase that does not use template information to synthesize new strands of DNA and may provide information useful in classifying haematological neoplasms.
Micromethod for quantitation of adenosine deaminase activity in cells from human peripheral blood.
- M. Coleman, J. Hutton
- BiologyBiochemical Medicine
- 1 May 1975
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