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IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells
IL-1β promotes chronic intestinal inflammation through recruitment of granulocytes, activation of ILCs, accumulation of pathogenic T cells, and promotion of Th17 responses.
Oncostatin M drives intestinal inflammation in mice and its abundance predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease
It is shown that, relative to healthy controls, inflamed intestinal tissues from patients with IBD express high amounts of the cytokine oncostatin M (OSM) and its receptor (OSMR), which correlate closely with histopathological disease severity.
X-linked cataract and Nance-Horan syndrome are allelic disorders
It is shown that NHS and X-linked cataract are allelic diseases, and different mechanisms, aberrant transcription of the NHS gene or no functional NHS protein, lead to different diseases.
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens
Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo and it is shown that diverse PEI forms have potent mucosal adjuvant activity for viral subunit glycoprotein antigens.
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
A unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4’-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01 is reported.
The Nance–Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology
It is demonstrated that NHS controls cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation, and suggested that NHS orchestrates actin regulatory protein function in response to signalling events during development.
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Functional validation using monoclonal antibodies confirmed the protective role of Fc-mediated antibody functions in restricting parasite infection both in vitro and in vivo, suggesting that these correlates may mechanistically contribute to parasite restriction and can be used to guide the rational design of an improved vaccine against malaria.
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease
Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01
This work unravels the key role of lymph node sentinel macrophage in controlling the adjuvant effect of a molecule proven to improve vaccine response in humans.