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Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum
Summary Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential forExpand
Influence of host iron status on Plasmodium falciparum infection
Iron deficiency affects one quarter of the world's population and causes significant morbidity, including detrimental effects on immune function and cognitive development. Accordingly, the WorldExpand
Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays
ABSTRACT Plasmodium vivax chloroquine resistance has been documented in nearly every region where this malaria-causing parasite is endemic. Unfortunately, P. vivax resistance surveillance and drugExpand
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection
ABSTRACT Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it isExpand
A Quality Control Program within a Clinical Trial Consortium for PCR Protocols To Detect Plasmodium Species
ABSTRACT Malaria parasite infections that are only detectable by molecular methods are highly prevalent and represent a potential transmission reservoir. The methods used to detect these infectionsExpand
Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum
Iron is a critical and tightly regulated nutrient for both the malaria parasite and its human host. The importance of the relationship between host iron and the parasite has been underscored recentlyExpand
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition
Significance Sickle cell trait has repeatedly been identified as a major human malaria resistance factor. Despite this, the exact mechanism of resistance is unclear. These studies demonstrate how theExpand
Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion
Malaria pathogenesis is caused by the replication of Plasmodium parasites within the red blood cells (RBCs) of the vertebrate host. This selective pressure has favored the evolution of protectiveExpand
Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle
Approximately one-third of the global population is at risk of Plasmodium vivax infection, and an estimated 7.51 million cases were reported in 2017. Although, P. vivax research is currently limitedExpand
Biopreservation of RBCs for in vitro Plasmodium falciparum culture
Falciparum malaria remains a devastating infectious disease, killing nearly 700 000 people annually. Further understanding of malaria pathogenesis will help identify molecular and cellular targets ofExpand