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Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum
TLDR
It is shown that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by repressing parasite sexual differentiation, and a major component of the sexual differentiation pathway in Plasmodium is introduced that may provide new approaches for blocking malaria transmission. Expand
Influence of host iron status on Plasmodium falciparum infection
TLDR
A large body of clinical and epidemiological evidence has accumulated which clearly demonstrates that host iron deficiency is protective against falciparum malaria and that hostIron supplementation may increase the risk of malaria. Expand
Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays
TLDR
A robust enrichment method is established and sensitive and robust measurements of parasite maturation are used to measure the sensitivities of Brazilian P. vivax isolate sensitivities to antimalarials for resistance surveillance and drug discovery. Expand
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection
TLDR
It is suggested that the bone marrow is an important reservoir for gametocyte development and proliferation of malaria parasites, and a systematic examination of tissue sequestration during P. vivax infection has important implications for parasite diagnosis and treatment. Expand
Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum
TLDR
The method for detecting the LIP within malaria parasitized RBCs provides evidence that the parasite is able to access serum iron sources as part of the host vs. parasite arms race for iron. Expand
A Quality Control Program within a Clinical Trial Consortium for PCR Protocols To Detect Plasmodium Species
ABSTRACT Malaria parasite infections that are only detectable by molecular methods are highly prevalent and represent a potential transmission reservoir. The methods used to detect these infectionsExpand
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition
TLDR
It is concluded that the protective effect of AS derives largely from effective sequestration of infected RBCs into the hypoxic microcirculation, and polymerization of sickle hemoglobin (HbS) is responsible for this growth arrest of intraerythrocytic P. falciparum parasites. Expand
Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion
TLDR
The peripheral blood immortalization method presented here offers the capacity to generate biologically representative model systems for studies of blood‐stage malaria invasion from the peripheral blood of donors harboring unique genetic backgrounds, or rare polymorphisms. Expand
Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle
TLDR
The feasibility and utility of P. vivax RNAseq-based transcriptomic studies using minimal biomass input to maximize experimental capacity are demonstrated. Expand
Biopreservation of RBCs for in vitro Plasmodium falciparum culture
TLDR
Prolonged RBC shelf-life and biopreservation could enhance malaria research by enabling standardization of the RBC source for multiple experiments, and increasing access to RBCs from individuals with unusual blood types, nutritional deficiencies, or from remote locations. Expand
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