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- Publications
- Influence
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
- S. Aparicio, J. Chapman, +38 authors S. Brenner
- Biology, Medicine
- Science
- 23 August 2002
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNA… Expand
Dosage sex-chromosome systems in plants
Abstract Dosage sex-chromosome systems have been detected in two genera of flowering plants. Rumex and Humulus . In Rumex subgenus Acetosa dioecious species have a multiple sex chromosome system with… Expand
Insights into shell deposition in the Antarctic bivalve Laternula elliptica: gene discovery in the mantle transcriptome using 454 pyrosequencing
- M. Clark, M. Thorne, F. Vieira, J. Cardoso, D. Power, L. Peck
- Biology, Medicine
- BMC Genomics
- 8 June 2010
BackgroundThe Antarctic clam, Laternula elliptica, is an infaunal stenothermal bivalve mollusc with a circumpolar distribution. It plays a significant role in bentho-pelagic coupling and hence has… Expand
Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.
- Y. Yamanishi, D. Boyle, +4 authors G. Firestein
- Medicine
- Journal of immunology
- 2002
Aggrecanases are key matrix-degrading enzymes that act by cleaving aggrecan at the Glu(373)-Ala(374) site. While these fragments have been detected in osteoarthritis (OA) and rheumatoid arthritis… Expand
Acclimation and thermal tolerance in Antarctic marine ectotherms
- L. Peck, S. Morley, J. Richard, M. Clark
- Biology, Medicine
- Journal of Experimental Biology
- 1 January 2014
Antarctic marine species have evolved in one of the coldest and most temperature-stable marine environments on Earth. They have long been classified as being stenothermal, or having a poor capacity… Expand
Antarctic marine molluscs do have an HSP70 heat shock response
- M. Clark, Keiron P. P. Fraser, L. Peck
- Biology, Medicine
- Cell Stress and Chaperones
- 2008
The success of any organism depends not only on niche adaptation but also the ability to survive environmental perturbation from homeostasis, a situation generically described as stress. Although… Expand
The HSP70 heat shock response in the Antarctic fish Harpagifer antarcticus
- M. Clark, Keiron P. P. Fraser, G. Burns, L. Peck
- Biology
- Polar Biology
- 10 August 2007
Members of the HSP70 gene family comprising the constitutive (HSC70) and inducible (HSP70) genes, plus GRP78 (Glucose-regulated protein 78 kDa) were surveyed for expression levels via Q-PCR after… Expand
Evolution of secretin family GPCR members in the metazoa
- J. Cardoso, V. C. Pinto, F. Vieira, M. Clark, D. Power
- Biology, Medicine
- BMC Evolutionary Biology
- 13 December 2006
BackgroundComparative approaches using protostome and deuterostome data have greatly contributed to understanding gene function and organismal complexity. The family 2 G-protein coupled receptors… Expand
Upper Temperature Limits of Tropical Marine Ectotherms: Global Warming Implications
Animal physiology, ecology and evolution are affected by temperature and it is expected that community structure will be strongly influenced by global warming. This is particularly relevant in the… Expand
Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster
- J. Zhang, K. Marshall, J. T. Westwood, M. Clark, B. Sinclair
- Biology, Medicine
- Journal of Experimental Biology
- 1 December 2011
SUMMARY Insects in the field are exposed to multiple bouts of cold, and there is increasing evidence that the fitness consequences of repeated cold exposure differ from the impacts of a single cold… Expand