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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
TLDR
It is suggested that while AMPK plays a key role in hypothalamic function, it does not act as a general sensor and integrator of energy homeostasis in the mediobasal hypothalamus. Expand
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
TLDR
It is shown in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Expand
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
TLDR
A critical role for p110 α in growth factor and metabolic signalling is demonstrated and an explanation for selective mutation or overexpression of p110α in a variety of cancers is suggested. Expand
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
TLDR
It is shown that mitochondria-ER contacts in anorexigenic pro-opiomelanocortin neurons in the hypothalamus are decreased in diet-induced obesity, establishing MFN2 in POMC neurons as an essential regulator of systemic energy balance by fine-tuning the mitochondrial-ER axis homeostasis and function. Expand
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
TLDR
The results suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age–related processes. Expand
Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.
TLDR
Current knowledge on the homeostatic regulation of energy balance is reviewed, emphasizing recent advances in mouse genetics, electrophysiology, and optogenetic techniques that have greatly contributed to improving understanding of this central process. Expand
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
TLDR
The existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity is shown, thus reinforcing the beneficial role of this bacterium on metabolism. Expand
The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
TLDR
A critical role for IRS2 is demonstrated in beta cell and hypothalamic function and insights are provided into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis. Expand
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.
TLDR
It is suggested that VHL/HIF oxygen-sensing mechanisms play a critical role in glucose homeostasis and that activation of this pathway in response to decreased islet oxygenation may contribute to beta cell dysfunction. Expand
Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
TLDR
Different metabolic roles for the p110α and p110β isoforms of PI3K in hypothalamic energy regulation are demonstrated, demonstrating a dominant role for the latter in energy homeostasis regulation. Expand
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