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  • A. Echalier, K. Bettayeb, +9 authors L. Meijer
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2008 (First Publication: 31 January 2008)
  • We report the synthesis and biological characterization of 3-(pyrimidin-4-yl)-7-azaindoles (meriolins), a chemical hybrid between the natural products meridianins and variolins, derived from marineExpand
  • Dominique Brossard, Laïla El Kihel, +4 authors Sylvain Rault
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2010 (First Publication: 1 July 2010)
  • The novelty of this work derives from the use of nitrogenous heterocycles as building block in the synthesis of conjugate bile acid derivatives. New piperazinyl bile acid derivatives were synthesizedExpand
  • V. Forest, M. Clément, Fabrice Pierre, K. Meflah, J. Ménanteau
  • Medicine, Biology
  • Nutrition and cancer
  • 2003 (First Publication: 1 January 2003)
  • Loss of function of the Apc gene product is an early and frequent event in colorectal carcinogenesis. Altered migration of intestinal epithelial cells has been described in vivo in the Min mouseExpand
  • L. El Kihel, M. Clément, M. Bazin, G. Descamps, Mohamed Khalid, S. Rault
  • Medicine, Chemistry
  • Bioorganic & medicinal chemistry
  • 2008 (First Publication: 15 September 2008)
  • Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinomaExpand