Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi.
A novel class of antitumor metabolites from the fungus Nattrassia Mangiferae
Structure elucidation of a new antifungal sterol sulfate, Sch 575867, from a deep-water marine sponge (Family: Astroscleridae).
It is described as a red-orange, rock hard, 15cm spherical sponge, with a thin veneer of living tissue over an aragonite skeleton, which is porous and smooth, with 2cm diameter mounds.
Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum.
Two novel chemokine receptor CCR-5 inhibitors were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications and the structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis.
Two novel diketopiperazines isolated from the fungus Tolypocladium sp.
A novel class of platelet activating factor antagonists from Phoma sp.
Four novel platelet activating factor antagonists were isolated from the fermentation broth of the fungal culture, Phoma sp.
Isolation and structure elucidation of Sch 642305, a novel bacterial DNA primase inhibitor produced by Penicillium verrucosum.
A novel primase inhibitor, Sch 642305 (1), was isolated from the fermentation broth of the fungal culture Penicillium verrucosum and exhibited inhibitory activity against bacterial DNA primase enzyme with an EC(50) of 70 microM.
A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.
As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.
Structure Elucidation of Sch 725674 from Aspergillus sp.
- Shu-wei Yang, T. Chan, J. Terracciano, D. Loebenberg, Mahesh Patel, M. Chu
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 August 2005
The structure elucidation of 1 was accomplished based on extensive NMR spectroscopic analyses and showed inhibitory activity against Saccharomyces cerevisiae and Candida albicans with MICs of 8 and 32 µg/ml, respectively.