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Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes
The results suggest that the activation of PAR1 mediates thrombin-induced MMP-9 expression through the regulation of Erk1/2. Expand
Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models
Mechanistic insight is provided into the neuroprotective role of SNO-DJ-1 by elucidating how DJ-1 detoxifies NO via transnitrosylation to PTEN, thus promoting cell survival. Expand
Down-regulation of matrix metalloproteinase-9 expression by nitric oxide in lipopolysaccharide-stimulated rat primary astrocytes.
  • C. Shin, W. Lee, +6 authors K. Ko
  • Chemistry, Medicine
  • Nitric oxide : biology and chemistry
  • 1 June 2007
The inhibitory effect of NO was mediated by the down-regulation of mRNA and protein levels of MMP-9 but not by the direct modification of the enzymatic activity of M MP-9, suggesting NO regulates MMPs expression via guanylate cyclase-PKG pathway. Expand
ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9
The results from the present investigation may provide further insights into the regulation of the activity of MMP-9 during microglial migration, which may play essential role in theregulation of inflammatory responses in pathological situations such as neurodegenerative disorders. Expand
Glucose deprivation increases hydrogen peroxide level in immunostimulated rat primary astrocytes
It is strongly indicated that glucose deprivation causes deterioration of immunostimulated astrocytes by increasing the intracellular concentration of H2O2. Expand
Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes
Results suggest that activation of PAR-2 by trypsin caused reversal of stellation in cultured astrocytes, in part, via the mobilization of intracellular Ca2+ and activation of PKC. Expand
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/glucose deprivation-induced death in rat primary astrocytes
The results suggest that the activation of MAPKs plays an important role in SIN-1/glucose deprivation-induced cell death by regulating the intracellular ATP level. Expand
Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase.
The present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase. Expand
Role of p38 mapk on the down-regulation of matrix metallo-proteinase-9 expression in rat astrocytes
  • C. Shin, W. Lee, +7 authors K. Ko
  • Biology, Medicine
  • Archives of pharmacal research
  • 1 May 2007
Results suggest that p38 activation down-regulates the inflammatory stimulation-induced over-expression of MMP-9, both in primary astrocytes and in cerebral cortex, and provides a more sophisticated mechanism for regulating M MP-9 activity in neuroinflammatory diseases. Expand
Essential role of mitogen-activated protein kinase pathways in protease activated receptor 2-mediated nitric-oxide production from rat primary astrocytes.
The results suggest that PAR-2 activation-mediated NO production in astrocytes is transduced by the activation of MAPKs followed by NF-kappaB pathways. Expand