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Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of
TLDR
The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.
Molecular mechanisms of inhibitory activities of tanshinones on Lipopolysaccharide-lnduced nitric oxide generation in RAW 264.7 cells
TLDR
It is suggested that tanshinones inhibit LPS-induced nitric oxide generation by interfering with the initial stage of L PS-induced expression of certain genes, andNF-kB and ERK could be the molecular targets for tanhinones for the inhibition of LPS -induced nitrics oxide production in macrophage cells.
The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice.
  • U. Jung, N. Baek, M. Choi
  • Medicine, Biology
    Food and chemical toxicology : an international…
  • 1 October 2007
Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats.
  • Y. Shin, S. Bok, Y. B. Park
  • Medicine, Biology
    International journal for vitamin and nutrition…
  • 1 September 1999
TLDR
The effects of the citrus bioflavonoid naringin were tested by using it as a supplement in a high-cholesterol diet and it was found that the combination of the inhibited HMG-CoA reductase and ACAT activities could account for the decrease of fecal neutral sterols.
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