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Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
TLDR
Most of the cardenolides obtained showed pronounced cytotoxicity against four cancer cell lines and the relative configuration of calactinic acid methyl ester has been confirmed by X-ray diffraction analysis on its derivative 13.
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Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides
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Structural Elucidation and Structure-Anti-inflammatory Activity Relationships of Cembranoids from Cultured Soft Corals Sinularia sandensis and Sinularia flexibilis.
TLDR
Structural-activity relationship analysis indicated that cembrane-type compounds with one seven-membered lactone moiety at C-1 are potential anti-inflammatory agents.
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Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.
Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and…
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Durumolides A–E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum
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Kadsuphilactones A and B, two new triterpene dilactones from kadsuraphilippinensis.
TLDR
Two novel triterpene dilactones, kadsuphilactones A and B, were isolated from the Taiwanese medicinal plant Kadsura philippinensis and exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.
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Bioactive 6S-styryllactone constituents of Polyalthia parviflora.
TLDR
The structure-activity relationship of the compounds in an in vitro anti-inflammatory assay revealed the 6S-styryllactones to be more potent than the 6R derivatives, however, the effect was opposite regarding their cytotoxic activity.
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Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinularia gibberosa.
Bioactivity-guided fractionation of a chloroform extract of the soft coral Simularia gibberosa afforded a new cytotoxic cembranoid diterpene, sinugibberol [1]. The structure of 1 was determined by…
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Nardosinane sesquiterpenoids from the Formosan soft coral Lemnalia flava.
TLDR
Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava and 1 and 2 were shown to possess significant neuroprotective activity.
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Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi.
TLDR
Chemical investigation of the octocoral Sarcophyton ehrenbergi has led to the isolation of a known ceramide and two new cerebrosides, sarcoehrenosides A and B, along with three known cereBrosides (3, 5, and 6).
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