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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons*
TLDR
A mouse model bearing a germline disruption in parkin is generated, providing the first evidence for a novel role of parkin in dopamine regulation and nigrostriatal function, and a non-essential role in the survival of nigral neurons in mice.
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Time course of early motor and neuropathological anomalies in a knock‐in mouse model of Huntington's disease with 140 CAG repeats
TLDR
A new knock‐in mouse model of HD with a chimeric mouse/human exon 1 containing 140 CAG repeats inserted in the murine huntingtin gene provides a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD.
View on Wiley
Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY
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Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.
TLDR
Results indicate that passive and active membrane and synaptic properties of medium-sized spiny neurons are altered in the R6/2 transgenic, which will affect communication in the basal ganglia circuitry and suggest areas to target for pharmacotherapies to alleviate and reduce the symptoms of HD.
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Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein
TLDR
These behavioral deficits provide a useful way to assess novel drug therapy in genetic models of synucleinopathies and indicate that overexpression of α-synuclein induced an early and progressive behavioral phenotype that can be detected in multiple tests of sensorimotor function.
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Synchronous Neuronal Activity Is a Signal for Axonal Sprouting after Cortical Lesions in the Adult
TLDR
Both after different types of lesions and in the blockade experiments axonal sprouting was strongly correlated with synchronous neuronal activity, suggesting a role for this activity in anatomical reorganization after brain lesion in the adult.
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Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone
View on Elsevier
Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.
TLDR
These behavioral deficits provide a useful way to assess novel drug therapy in genetic models of synucleinopathies and indicate that overexpression of alpha-synuclein induced an early and progressive behavioral phenotype that can be detected in multiple tests of sensorimotor function.
View on PubMed
Animal models of Parkinson’s disease progression
TLDR
This review critically evaluates in vivo models and the roles they play in mimicking the progression of PD and indicates that toxin-induced and genetically manipulated models are critical for the development of neuroprotective strategies.
View on Springer
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