M. Cherney

Publications188
h-index33
Citations4,027
Highly Influential Citations265
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Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
TLDR
The crystal structure of Stx2 from E. coli O157:H7 was determined and it was found that, in contrast to Stx, the active site of the A-subunit of StX2 is accessible in the holotoxin, and a molecule of formic acid and a water molecule mimic the binding of the adenine base of the substrate.
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Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
TLDR
Comparisons between the structures of the alternate conformational states of rabbit hemorrhagic disease virus RdRP and the structure of RdRPs from hepatitis C virus and polio virus suggest novel structure-function relationships in this medically important class of enzymes.
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Crystal Structure of LexA A Conformational Switch for Regulation of Self-Cleavage
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Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
TLDR
The structures of the NS5B polymerase/non-nucleoside inhibitor complexes bind at a common binding site, which is nearly 35 Å away from the polymerase active site and is located in the thumb domain, and the enzyme inhibitor complexes are stabilized by hydrogen bonding and van der Waals interactions.
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Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
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Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
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The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut‐off of host‐cell protein synthesis
TLDR
The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2‐2Apro) has been solved to 1.95 Å resolution and suggests the mechanism of the cis cleavage and its release from the polyprotein.
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Refined X-ray crystallographic structure of the poliovirus 3C gene product.
The X-ray crystallographic structure of the recombinant poliovirus 3C gene product (Mahoney strain) has been determined by single isomorphous replacement and non-crystallographic symmetry averaging…
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Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.
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Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide
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