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Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
TLDR
The crystal structure of Stx2 from E. coli O157:H7 was determined and it was found that, in contrast to Stx, the active site of the A-subunit of StX2 is accessible in the holotoxin, and a molecule of formic acid and a water molecule mimic the binding of the adenine base of the substrate.
Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
TLDR
Comparisons between the structures of the alternate conformational states of rabbit hemorrhagic disease virus RdRP and the structure of RdRPs from hepatitis C virus and polio virus suggest novel structure-function relationships in this medically important class of enzymes.
Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
TLDR
The structures of the NS5B polymerase/non-nucleoside inhibitor complexes bind at a common binding site, which is nearly 35 Å away from the polymerase active site and is located in the thumb domain, and the enzyme inhibitor complexes are stabilized by hydrogen bonding and van der Waals interactions.
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut‐off of host‐cell protein synthesis
TLDR
The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2‐2Apro) has been solved to 1.95 Å resolution and suggests the mechanism of the cis cleavage and its release from the polyprotein.
Refined X-ray crystallographic structure of the poliovirus 3C gene product.
The X-ray crystallographic structure of the recombinant poliovirus 3C gene product (Mahoney strain) has been determined by single isomorphous replacement and non-crystallographic symmetry averaging
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