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Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
The crystal structure of Stx2 from E. coli O157:H7 was determined and it was found that, in contrast to Stx, the active site of the A-subunit of StX2 is accessible in the holotoxin, and a molecule of formic acid and a water molecule mimic the binding of the adenine base of the substrate.
Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
Comparisons between the structures of the alternate conformational states of rabbit hemorrhagic disease virus RdRP and the structure of RdRPs from hepatitis C virus and polio virus suggest novel structure-function relationships in this medically important class of enzymes.
Crystal Structure of LexA A Conformational Switch for Regulation of Self-Cleavage
Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
The structures of the NS5B polymerase/non-nucleoside inhibitor complexes bind at a common binding site, which is nearly 35 Å away from the polymerase active site and is located in the thumb domain, and the enzyme inhibitor complexes are stabilized by hydrogen bonding and van der Waals interactions.
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut‐off of host‐cell protein synthesis
- J. Petersen, M. Cherney, H. Liebig, T. Skern, E. Kuechler, M. James
- Chemistry, BiologyThe EMBO journal
- 15 October 1999
The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2‐2Apro) has been solved to 1.95 Å resolution and suggests the mechanism of the cis cleavage and its release from the polyprotein.
Refined X-ray crystallographic structure of the poliovirus 3C gene product.
- S. Mosimann, M. Cherney, S. Sia, S. Plotch, M. James
- ChemistryJournal of molecular biology
- 14 November 1997
The X-ray crystallographic structure of the recombinant poliovirus 3C gene product (Mahoney strain) has been determined by single isomorphous replacement and non-crystallographic symmetry averaging…
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.