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Immunogenicity of recombinant adenovirus-human immunodeficiency virus vaccines in chimpanzees following intranasal administration.
TLDR
Substantial local immune responses were induced in nasal, vaginal, and salivary secretions following the third Ad-HIV intranasal immunization, and these responses were further boosted with the gp160 subunit vaccine, which also stimulated production of rectal antibodies.
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Biochemical characterization of osteo-testicular protein tyrosine phosphatase and its functional significance in rat primary osteoblasts.
TLDR
It is shown that the first domain of OST-PTP is enzymatically active and appears to be influenced by the catalytically inactive second domain (CD2), and the activity of CD1 is specific to phosphorylated tyrosine.
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Immunogenicity and efficacy testing in chimpanzees of an oral hepatitis B vaccine based on live recombinant adenovirus.
  • M. Lubeck, A. Davis, P. Hung
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 September 1989
TLDR
It is demonstrated here that chimpanzees are susceptible to enteric infection by human adenoviruses type 7 (Ad7) and type 4 (Ad4) following oral administration of live virus, and the feasibility of using orally administered recombinant adenOViruses as a general approach to vaccination is demonstrated.
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Immunogenicity of recombinant human adenovirus-human immunodeficiency virus vaccines in chimpanzees.
TLDR
Recombinant human adenovirus (Ad) type 4, 5, and 7-vectored vaccines expressing either the HIV env or gag-protease genes were tested for immunogenicity in three chimpanzees, and both virus shedding and anti-adenovirus responses were enhanced.
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GnRH agonists and antagonists in cancer therapy.
TLDR
In recent years, a search for peptidomimetic compounds to replace peptides as therapeutic agents has been undertaken to find compounds with higher affinity for the GnRH receptor but do not have the disadvantages of peptides, resulting in the identification and development of small-molecule non-peptide compounds that are sufficiently stable in vivo and possess favorable pharmacological parameters comparable to peptide antagonists.
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A multi-well filtration assay for quantitation of inositol phosphates in biological samples.
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Enhanced immunogenicity of hepatitis B surface antigen by insertion of a helper T cell epitope from tetanus toxoid.
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Evaluation of adenovirus type 4 and type 7 recombinant hepatitis B vaccines in dogs.
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Adenovirus vaccine vectors expressing hepatitis B surface antigen: importance of regulatory elements in the adenovirus major late intron.
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Immunogenicity of high expression adenovirus-hepatitis B virus recombinant vaccines in dogs.
TLDR
This study establishes that the E3-deleted high yield Ad4 and Ad7 recombinants represent promising live oral hepatitis B vaccine candidates and thus the dog represents a valuable model for evaluation of immune responses to heterologous proteins that are expressed early and that do not require efficient DNA replication.
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