• Publications
  • Influence
Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression
It is found that curcumin repressed the expression of HER2 and inhibited the kinase activity of PAK1 without affecting its expression, which provided novel insights into the mechanisms ofCurcumin inhibition of gastric cancer cell growth and potential therapeutic strategies for Gastric cancer.
Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors
The potentiality of these PTP1B inhibitors as lead compounds for further drug developments is suggested, based on kinetic analyses and structure–activity relationship.
Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents.
Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
The discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold and one of the best compounds, 31 (CZh226), showed remarkablePAK4 selectivity and favorable kinase selectivity profile support the further development of 31 as a lead compound for PAK 4-targeted anticancer drug discovery and as a valuable research probe for the further biological investigation of group II PAKs.
Facile Synthesis of Oleanolic Acid Monoglycosides and Diglycosides
This method is suitable for preparing oleanolic acid glycosides with structural diversity for extensive biological evaluation and structure-activity relationship study, and it also apply new idea for the corresponding synthetic methods to the glycoside derivatives of other triterpenoid.
Facile Synthesis of the Naturally Cytotoxic Triterpenoid Saponin Patrinia-Glycoside B-II and Its Conformer
Preliminary structure-activity relationships studies indicated that the 4C1 chair conformation of the arabinose residue in the unique α-l-rhamnopyranosyl-(1→2)-β-d-gluco-pyranoside-α- l-arabinopyrnosyl disaccharide moiety is one of the chief positive factors responsible for its cytotoxic activity against tumors.
Comparison of the Effects of Pantoprazole Enantiomers on Gastric Mucosal Lesions and Gastric Epithelial Cells in Rats
The results of in vitro experiments were not in complete accordance with the in vivo results, suggesting that the effects of the three drugs on ulcer inhibition are mainly due to the results of acid inhibition rather than cytoprotection.