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Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.
TLDR
The results suggest that the release of soluble IL-6R might be linked to regulatory functions of immune responses induced by IL- 6 stimulation during normal and human retrovirus-infected cell growth and differentiation. Expand
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
TLDR
Analysis of p19ARF deletion mutants indicated that the unique aminoterminal domain encoded by exon 1 beta was both necessary and sufficient for inducing G1 arrest, indicating that cancer-associated mutations within exon 2 of the INK4a gene specifically target p16INK4a, and not p19 ARF, for inactivation. Expand
Pro‐protein convertase gene expression in human breast cancer
TLDR
The results suggest that elevated expression of some members of the pro‐protein convertase gene family is a characteristic of human breast cancer, an event which may be important for human breast tumorigenesis. Expand
Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3*
TLDR
The molecular epitope of 8H9 was determined to be dependent on the FG loop of B7-H3, a region critical to its function in immunologic blockade and unique among anti-B7- H3 antibodies published to date. Expand
Retargeting NK92 cells using an HLA-A2-restricted, EBNA3C-specific chimeric antigen receptor
TLDR
For the first time, the successful reprogramming of non-T cells toward a specific TCE using a CAR is shown, with detection sensitivity of approximately 25 molecules and cytolytic capacity threefold greater than scFv-Fc-mediated ADCC. Expand
Retargeting T Cells to GD2 Pentasaccharide on Human Tumors Using Bispecific Humanized Antibody
TLDR
The in vitro and in vivo antitumor properties of hu3F8-BsAb and its safety profile support its further clinical development as a cancer therapeutic, and provide the rationale for exploring aglycosylated IgG-scFv as a structural platform for retargeting human T cells. Expand
Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody
TLDR
The dimerization domain of the human transcription factor HNF1α is exploited to enhance the avidity of a tsc-BsAb to the tumor antigen disialoganglioside GD2 while maintaining functional monovalency to CD3 to limit potential toxicity. Expand
Structural design of disialoganglioside GD2 and CD3‐bispecific antibodies to redirect T cells for tumor therapy
TLDR
It is shown that the VH–VL orientation, the (GGGGS)3 linker, disulfide bond stabilization of scFv, when combined with an affinity matured mutation provided the most efficient BsAb to direct T cells to lyse GD2‐positive tumor cells. Expand
Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress.
TLDR
This study provided a novel insight for improving cytotoxicity by combining JFK with DDP to treat lung cancer cells and demonstrated that AIFM2 is activated by the combined treatment of JFK and DDP and partially mediates the synergistic pro-apoptosis effect. Expand
Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer
TLDR
The results revealed that upregulated IGF2BP1 promotes the proliferation of pancreatic cancer cells via the AKT signaling pathway and confirmed that the activation of IGF2 BP1 is partly due to the silencing of miR-494. Expand
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